January 2007 CEBP Highlights

Selected Articles from the January 2007 Issue

The articles referenced in this Highlights section will be available online in HTML and PDF formats to all interested users at no charge until the next issue of Cancer Epidemiology, Biomarkers & Prevention is published. Click on the article title to view the complete article.

View the Table of Contents for the January 2007 issue of Cancer Epidemiology, Biomarkers & Prevention.

Household Activity Protects Against Breast Cancer Risk

Lahmann et al.

Page 36

There is convincing evidence for a decreased risk of breast cancer with increased physical activity. Uncertainties remain, however, regarding the role of different types of physical activity on breast cancer risk, and potential effect modification of these associations. Lahmann et al. used data from 218,169 pre- and postmenopausal women from nine European countries, aged 20–80 years at study entry into the European Prospective Investigation into Cancer and Nutrition (EPIC). Overall, increasing total physical activity was associated with a reduction in breast cancer risk among postmenopausal women. Specifically, household activity was associated with a statistically significantly reduced risk in postmenopausal and premenopausal women. Occupational activity and recreational activity were not related to breast cancer risk in either pre- or postmenopausal women. This study provides additional evidence for a protective effect of physical activity on breast cancer risk.

Shedding Pounds Lowers Risks of Prostate Cancer

Rodriguez et al.

Page 63

Obesity has been associated with aggressive prostate cancer. The extent to which this association varies by stage and grade remains unclear. The role of recent weight change has not been examined previously. The association between BMI in 1992 and risk of prostate cancer differed by stage and grade at diagnosis: BMI was inversely associated with risk of nonmetastatic low-grade prostate cancer, but was positively associated with risk of nonmetastatic high-grade prostate cancer and risk of metastatic or fatal prostate cancer. Compared with weight maintenance, men who lost 11 or more pounds between 1982-92 were at decreased risk of non-metastatic high-grade prostate cancer. Obesity increases the risk of more aggressive prostate cancer and may decrease either the occurrence, or likelihood of diagnosis, of less-aggressive tumors. Men who lose weight may reduce their risk of prostate cancer.

Anthropometrics Answers More Questions

Werny et al.

Page 70

Recent studies have shown an inverse association between body mass index (BMI) and prostate-specific antigen (PSA), a commonly used serum marker for the detection and diagnosis of prostate cancer. Werny et al. examined the association between several anthropometric measures and PSA in a nationally representative sample of men. Among white men, the authors report a trend of decreasing PSA with increasing weight, BMI, waist circumference, triceps skinfold thickness, and calculated total body water. Among Mexican American men, there was a trend of decreasing PSA with increasing BMI, and among black men, a trend of decreasing PSA with increasing triceps thickness. Controlling for age and race/ethnicity in the multiple linear regression model, they found moderate declines in PSA with increases in BMI, weight, waist circumference, triceps skinfold, and calculated total body water. A prospective study is needed to establish whether obesity affects the accuracy of PSA as a screening and diagnostic tool.

January 2007 CEBP Highlights

Selected Articles from the January 2007 Issue

Household Activity Protects Against Breast Cancer Risk

Shedding Pounds Lowers Risks of Prostate Cancer

Anthropometrics Answers More Questions

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