PDF Version for Printing
The articles referenced in this Highlights section will be available online in HTML and PDF formats to all interested users at no charge until the next issue of Cancer Epidemiology, Biomarkers & Prevention is published. Click on the article title to view the complete article.
View the Table of Contents for the July 2007 issue of Cancer Epidemiology, Biomarkers & Prevention.
Page 1364
Page 1400
Page 1449
Page 1474
Multiple myeloma is the second most common hematopoietic malignancy, but its etiology remains poorly understood. The identification of modifiable risk factors for this disease is particularly urgent given that 5-year survival rates are well below 40%. Several population-based studies suggested that body mass index (BMI) or energy balance is a potentially modifiable risk factor. Birmann and colleagues further examined the role of energy balance in the etiology of multiple myeloma through prospective analyses of the relation of both BMI and physical activity with risk. The authors observed a positive association of BMI with multiple myeloma (consistent with previous publications) that appears to be independent of physical activity. Obesity appears to have an etiologic role in multiple myeloma, but the role of other correlates of energy balance remains uncertain.
Douglas et al. Page 1510 Rare, inactivating mutations in the BRCA1 gene appear to play a limited role in prostate cancer. Douglas and colleagues used family-based association tests and conditional logistic regression to investigate the association between prostate cancer and single nucleotide polymorphisms (SNPs) tagging common haplotype variation in a 200 kb-region surrounding (and including) the BRCA1 gene. The strongest evidence for prostate cancer association was for a glutamine-to-arginine substitution at codon 356 (Gln356Arg) in exon 11 of the BRCA1 gene. Thus, the authors identified a common, non-synonymous substitution in the BRCA1 gene that is associated with and linked to prostate cancer.
Page 1510