PDF Version for Printing
The articles referenced in this Highlights section will be available online in HTML and PDF formats to all interested users at no charge until the next issue of Cancer Epidemiology, Biomarkers & Prevention is published. Click on the article title to view the complete article.
View the Table of Contents for the August 2007 issue of Cancer Epidemiology, Biomarkers & Prevention.
Page 1573
Page 1581
Page 1587
Page 1615
There is a paucity of data about the spectrum of BRCA mutations among Hispanics. Large rearrangements account for 8–15% of deleterious BRCA mutations, though none have been characterized previously in individuals of Mexican ancestry. Weitzel and colleagues identified and characterized a novel large BRCA1 deletion in five unrelated families—four of Mexican ancestry and one of African and Native American ancestry, suggesting the possibility of founder effect of Amerindian or mestizo origin. This BRCA1 rearrangement was detected in 3.8% of BRCA sequence-negative Hispanic families. An assay for this mutation should be considered for sequence-negative high-risk Hispanic patients.
Chow et al. Page 1662 Green tea consumption has been associated with decreased risk of certain types of cancers in humans. Induction of detoxification enzymes has been suggested as one of the biochemical mechanisms responsible for the cancer preventive effect of green tea. Chow and colleagues conducted this clinical study to determine the effect of repeated green tea polyphenol administration on a major group of detoxification enzymes, glutathione S-transferases (GSTs). The authors concluded that green tea polyphenol intervention may enhance the detoxification of carcinogens in individuals with low baseline detoxification capacity.
Page 1662