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View the Table of Contents for the September 2007 issue of Cancer Epidemiology, Biomarkers & Prevention.
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Greater body fatness during childhood is associated with reduced risk of premenopausal breast cancer, but few studies have addressed the relation of adiposity with sex hormones in girls. Baer and colleagues prospectively examined associations between adiposity and circulating levels of sex hormones and sex hormone-binding globulin (SHBG) among 286 girls in the Dietary Intervention Study in Children. Participants were 8 to 10 years old at baseline and were followed for an average of seven years. Estrogen and progesterone concentrations were similar across BMI quartiles. The findings, nonetheless, suggested that DHEAS and SHBG levels in girls may differ by degree of adiposity.
Madlensky et al. Page 1898 Colorectal adenomas and other types of polyps are commonly used as endpoints or risk factors in epidemiologic studies. However, it is not known how accurately patients are able to self-report the presence or absence of adenomas following colonoscopy. The positive predictive value for self-reported polyp was 80.9%, and the negative predictive value was 85.8%. Participants with a previous diagnosis of colorectal cancer had a lower negative predictive value (76.2%) than participants with no personal history of colorectal cancer (89.0%). Madlensky and coauthors concluded that predictive values for self-reports of polyps are fairly high, but researchers needing accurate polyp data should obtain medical record confirmation.
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