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The articles referenced in this Highlights section will be available online in HTML and PDF formats to all interested users at no charge until the next issue of Clinical Cancer Research is published. Click on the article title to view the complete article.
View the Table of Contents for the March 15 issue of Clinical Cancer Research.
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Resveratrol is an antioxidant found in a wide variety of plant species, including grapes. Here, Roccaro and colleagues show that resveratrol exhibits anti-neoplastic activity against Waldenström’s Macroglobulinemia (WM) primary cells. After resveratrol treatment, they observed a down-regulation of Akt, ERK/MAPK and Wnt signaling pathways and a reduction of Akt activity, which triggered activation of JNK and activation of intrinsic and extrinsic caspase pathways. Adherence to bone marrow stromal cells did not confer protection to WM cells against resveratrol-induced cytotoxicity. Furthermore, resveratrol showed synergistic cytotoxicity when combined with other agents widely used to fight WM. These preclinical data provide a rationale for evaluating the efficacy of resveratrol to treat WM in the clinic.
Lee et al. Page 1905 The bacterium Salmonella has previously been shown to have activity as a tumor-targeting anticancer agent in mouse models. Salmonella likely elicits antitumor effects by stimulating the immune system, but the specific immune mechanism through which Salmonella acts remains unclear. It is known, however, that Toll-like receptor 4 (TLR4) is a signaling receptor for lipopolysaccharides found on Salmonella. Lee and colleagues used wild-type mice and TLR4-deficient mice to study the role of TLR4 in the antitumor immune response induced by Salmonella. They found that Salmonella elicited chemokine expression, immune cell recruitment, and antiangiogenic activities via TLR4 signaling. These findings provide a clearer molecular understanding of how Salmonella stimulates the immune system to fight tumors.
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