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View the Table of Contents for the March 1 issue of Cancer Research.
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The cell adhesion molecule and adiponectin-binding protein T-cadherin is lost from the carcinogenic mammary epithelium and dramatically up-regulated in the tumor vasculature. Deficiency in mice restricts tumor growth in the MMTV-PyV-mT breast cancer model but also leads to a more invasive and metastatic tumor cell behavior. Hebbard and colleagues demonstrated that T-cadherin regulates tumor angiogenesis and its absence ablates the association of the adipocyte-derived, circulating metabolic hormone adiponectin with the tumor vasculature. This work links adiponectin with a proangiogenic role for T-cadherin, and provides a cautionary example that restricted angiogenesis might result in more aggressive disease.
Munday et al. Page 1593 Isothiocyanates are a well-known class of chemopreventive agents. Broccoli sprouts are a rich source of several isothiocyanates. To evaluate the inhibitory activity of broccoli sprouts against bladder cancer, Munday and colleagues fed a freeze-dried extract of broccoli sprouts to rats exposed to a nitrosamine carcinogen and found that the extract markedly inhibited bladder cancer development. The extract also significantly elevated several anticarcinogenic enzymes in the bladder. The isothiocyanates appear to be selectively delivered through urinary excretion to the bladder epithelium, the principal site of bladder cancer development. Thus, the extract is a highly promising substance for bladder cancer prevention.
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