CHAIRPERSONS:
Michael B. Kastan, St. Jude Children’s Research Hospital, Memphis, TN, USA
Joseph D. Rosenblatt, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, USA
Moshe Oren, Weizmann Institute of Science, Rehovot, Israel
Gideon Rechavi, The Chaim Sheba Medical Center, Tel Hashomer, Israel
The overall goal of the upcoming meeting in Jerusalem is to bring together top cancer scientists from the United States, Israel, Europe and neighboring Mediterranean and Middle Eastern countries to share in a productive and lively cancer research forum with emphasis on emerging technologies and opportunities for clinical translation and integration into oncologic practice.
The meeting will focus on the identification of new therapeutic targets, biomarkers, prognostic factors, and novel diagnostics. The growing integration of genomic and proteomic technologies into clinical care in the setting of lymphoma, breast cancer, and other solid tumors will be discussed. Novel approaches to patient stratification and the design of clinical trials which will allow more successful integration of newer modalities and more efficient testing of targeted agents will be presented.
Recent insights into tumor angiogenesis, the biology of tyrosine kinases such as HER2 and EGFR, mTOR, and other signaling pathways, DNA damage repair pathways, methylation and epigenetic regulation, which have significant potential for clinical exploitation will be highlighted by leaders in the field. Tumor-stromal interactions, the complex interplay between cancer and the innate and adaptive immune systems, as well as the role of inflammation in cancer pathogenesis present additional opportunities for intervention that will be explored. Evolving methods of metabolic and molecular imaging that are providing investigators with new approaches to rapid tumor detection as well as early assessment of response will also be presented.
The AACR is pleased to sponsor this historic regional forum for investigators working in translational cancer research. The scientific program will promote in-depth discussions among a diverse group of multidisciplinary clinical and basic investigators and provide an opportunity for young investigators from the United States, Israel, and elsewhere in the region to share ideas and interact with seasoned investigators.