PLENARY SESSION: MECHANISMS OF CHEMOPREVENTION WITH FOODS
8:00 a.m. to 10:00 a.m.
Chairperson: Edward L. Giovannucci, Harvard School of Public Health, Boston, MA
One-Carbon Nutrients and Colon Cancer: Mechanisms
Joel B. Mason, Tufts University, Boston, MA
Novel Tomato Products for Cancer Prevention
Steve K. Clinton, The Ohio State University, Columbus, OH
Novel Approaches for Chemoprevention of Colon Cancer by Food Components
Bandaru S. Reddy, Rutgers: The State University of New Jersey, Piscataway, NJ
CONCURRENT SESSIONS
10:15 a.m. to 12:15 p.m.
Anticancer Effects of Tea and Tea Constituents
Co-Chairpersons: Allan H. Conney, Rutgers University, Piscataway, NJ, and I. Bernard Weinstein, Columbia University, New York, NY
Overview
I. Bernard Weinstein
Inhibitory Effect of Caffeine on UVB-induced Carcinogenesis
Allan H. Conney
EGCG Inhibits Critical Pathways of Signal Transduction in Human Cancer Cells
I. Bernard Weinstein
Clinical Relevance of the Inhibitory Effects of Green Tea Catechins on Prostate Cancer Progression in “High Risk” Men in Combination with Molecular Profiling of Catechin-resistant Tumors
Saverio Bettuzzi, University of Parma, Parma, Italy
Challenges to the Dissemination of Results from Cancer Prevention Trials
Chairperson: Patricia A. Ganz, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA
Introduction / Overview of the Problem
Patricia A. Ganz
Monitoring Multiple Endpoints in Prevention Trials
Joseph P. Costantino, University of Pittsburgh, Pittsburgh, PA
Assessing Patient-Reported Outcomes in Prevention Trials
Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA
Putting it All Together: How Do Primary Care Physicians Interpret and Use the Results of Prevention Trials?
Linda S. Kinsinger, University of North Carolina School of Medicine, Chapel Hill, NC
Panel Discussion and Questions
Epigenomics and Imprinting
Chairperson: Randy L. Jirtle, Duke University, Durham, NC
Overview
Randy L. Jirtle
Abnormalities of Genomic Methylation Patterns in Mammary Carcinoma
Timothy H. Bestor, Columbia University, New York, NY
Computational Methods for Genome-wide Prediction of Imprinted Genes
Alexander J. Hartemink, Duke University, Durham, NC
Genome-Epigenome Interactions in Tumors with Excessive Proliferation
Joseph F. Costello, University of California, San Francisco, CA
Proffered Paper Presentation
Gynecologic Neoplasia: Pathogenesis, Precursors, and Prevention
Chairperson: Christopher P. Crum, Brigham and Women’s Hospital, Boston, MA
Overview
Christopher P. Crum
Molecular Resolution of Endometrial Cancer Precursors
George L. Mutter, Brigham and Women’s Hospital, Boston, MA
Serous Precursor Lesions in the Distal Fallopian Tube
Ronny I. Drapkin, Dana-Farber Cancer Institute, Boston, MA
Pharmacologic Opportunities for the Chemoprevention of Ovarian Cancer
Gustavo C. Rodriguez, Northwestern University, Chicago, IL
Proffered Paper Presentation
Health Disparities and Cancer Prevention
Chairperson: Electra D. Paskett, The Ohio State University, Columbus, OH
Overview
Electra D. Paskett
Promoting Healthy Nutrition in Mexican Immigrant Communities: Results of the “Secretos de la Buena Vida” Project
John P. Elder, San Diego State University Graduate School of Public Health, San Diego, CA
Community Influences and Cancer Screening Behaviors Among Hispanics
Beti Thompson, Fred Hutchinson Cancer Research Center, Seattle, WA
Racial Differences in Quality of Life Following Prostate Cancer Diagnosis
Chanita Hughes Halbert, University of Pennsylvania, Philadelphia, PA
Proffered Paper Presentation
CONCURRENT SESSIONS
1:00 p.m. to 3:00 p.m.
Cancer Survivorship
Chairperson: Paul F. Engstrom, Fox Chase Cancer Center, Philadelphia, PA
Overview
Paul F. Engstrom
Ready for a Change or Stuck in a Rut: Cancer Survivor Attitudes and Prevention Practices
Wendy Demark-Wahnefried, Duke University, Durham, NC
Cancer Center Survivor Follow-up and Surveillance
Mary McCabe, Memorial Sloan-Kettering Cancer Center, New York, NY
Chemoprevention to Save Our Lives!
David S. Alberts, Arizona Cancer Center, University of Arizona College of Medicine, Tucson, AZ
Cancer Patient/Cancer Survivor Perspectives
Doug Ulman, Lance Armstrong Foundation, Austin, TX
Proffered Paper Presentation
Global Cervical Cancer Control in the Era of HPV Vaccines
Chairperson: Laura A. Koutsky, University of Washington, Seattle, WA
Overview
Laura A. Koutsky
Prevention of HPV-Related Cancers Through Immunization
Laura A. Koutsky
Planning Cervical Cancer Screening in the Era of HPV Vaccines
Eduardo L. F. Franco, McGill University, Montreal, QC, Canada
Analytics to Inform Cervical Cancer Control Policy
Sue Goldie, Harvard School of Public Health, Boston, MA
Discussion
Systems Approaches to Prevention: Seeing the Forest AND the Trees
Chairperson: Kenneth H. Buetow, National Cancer Institute, Bethesda, MD
Overview
Kenneth H. Buetow
Integrative Mathematical Modeling of Cancer Invasion
Vito Quaranta, Vanderbilt University, Nashville, TN
A Systems Approach to Protein Kinase Signaling: Application to DNA Damage Responses
Michael P. Yaffe, Massachusetts Institute of Technology, Cambridge, MA
A Systems Approach to Cancer Therapies
Peter Sorger, Harvard University, Boston, MA
Regulation and Targeting the Hypoxia Inducible Factor Pathway
Margaret Ashcroft, Institute of Cancer Research Haddow Labs, Surrey, England
Targeting the IGF Axis to Prevent Cancer
Chairperson: Douglas Yee, University of Minnesota, Minneapolis, MN
Overview
Douglas Yee
Insulin, IGFs, and Energy Balance: Relevance to Cancer Risk
Michael N. Pollak, Jewish General Hospital, Montreal, QC, Canada
IGF Axis as a Target for Chemoprevention/Therapy in Aerodigestive Tract Cancer
Ho-Young Lee, UT M. D. Anderson Cancer Center, Houston, TX
Lowering IGF-I Levels for the Prevention of Breast Cancer
Adrian V. Lee, Baylor College of Medicine, Houston, TX
DEPARTURE