Laboratory and clinical research in malignant melanoma, focusing on immune checkpoint blockade, gene engineered T cells, and BRAF targeted therapies; clinical development of new drugs for the treatment of metastatic melanoma; developing models of disease to test new therapeutic options; studying the mechanism of action of treatments in patients and the molecular mechanisms of therapy resistance; defining mechanisms of response and resistance to modern immunotherapies.
Current Affiliations: Professor of Medicine (with Tenure), Surgery, and Molecular and Medical Pharmacology, University of California Los Angeles, CA; Director, Tumor Immunology Program, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA; Visiting Associate, Division of Biology, California Institute of Technology (Caltech), Pasadena, CA.
Previous Positions: Associate Professor of Medicine and Surgery (with Tenure) (2008-2011), Associate Professor in Residence of Medicine and Surgery (2006-2008), and Assistant Professor in Residence of Medicine and Surgery (2001-2006), Department of Medicine, Division of Hematology/Oncology, and Department of Surgery, Division of Surgical Oncology, University of California Los Angeles; Associate Director of Tumor Immunology Program (2006-2010) and Director of Cell and Gene Therapy Core Facility (2004-2010), UCLA Jonsson Comprehensive Cancer Center; Assistant Director for Clinical Programs, UCLA Human Gene Medicine Program (2001-2010), Los Angeles, CA.
Postdoctoral Training: Hematology/Oncology Fellow, Department of Medicine, Division of Hematology/Oncology, University of California Los Angeles (UCLA) (1998-2001); Postdoctoral Researcher, Department of Surgery, Division of Surgical Oncology, University of California Los Angeles (1996-1998); Intern and Resident in Medical Oncology, University Hospital Vall d’Hebron (1991-1994), Barcelona, Spain.
Selected AACR Service, Honors, and Awards: Cochair, Combination Therapies Think Tank (2019); Recipient, AACR-CRI Lloyd J. Old Award in Cancer Immunology (2018); Vice Chair (2018-2019) and Cochair (2015-2016), Annual Meeting Program Committee; Cochair, AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference (2017, 2018); Member, Board of Directors (2016-2019); Recipient, AACR Richard and Hinda Rosenthal Memorial Award (2016); Cochair, Tumor Immunology and Immunotherapy Conference (2016); Member, AACR NextGen Transformative Grants Scientific Review Committee (2015-2017); Cochair, Annual Meeting Education Committee (2015-2016); Member, Annual Meeting Clinical Trials Committee (2015-2017); Chair, AACR-CRI Lloyd J. Old Award in Cancer Immunology Review Committee (2013-2014); Scientific Editor, Cancer Discovery (2014-Present); Member, Steering Committee, Cancer Immunology Working Group (2014-2016); Member, Editorial Board, Clinical Cancer Research (2012-2014); Member, Clinical and Translational Cancer Research Grants Scientific Review Committee (2012-2014).
Selected Non-AACR Service, Honors, and Awards: Doctor Honoris Causa, University of Buenos Aires, Argentina (2017); Member, NCI/NCAB Blue Ribbon Panel Working Group (2016-2017); Recipient, Lila and Murray Gruber Memorial Cancer Research Award and Lectureship, American Academy of Dermatology (AAD) (2015); Elected Member, Royal Academy of Medicine of Catalonia (2015); Recipient, Giants of Cancer Care Award, OncLife (2015); Recipient, R35 Outstanding Researcher Award, NCI (2015); Member, Editorial Board, Proceedings of the National Academy of Sciences (2015-Present); Recipient, Outstanding Researcher Award, Society for Melanoma Research (2013); Vice President, Society for Melanoma Research (SMR) (2012-2015); Chair, Melanoma Committee, Southwest Oncology Group (SWOG) (2011-Present); Member, NCI Clinical Oncology Subcommittee (2010-2014); Member, Board of Directors, Society for Immunotherapy for Cancer (SITC) (2010-2013); Elected Member, American Society of Clinical Investigation (ASCI) (2009); Recipient, Mary Kay Ash Foundation Award (2007); Recipient, Junior Researcher Award, Melanoma Research Foundation (2005); Member, NCI Career Development Subcommittee I (2005-2009).
Education: PhD, Autonomous University of Barcelona, Barcelona, Spain (1997); MD, University of Barcelona, Barcelona, Spain (1990).