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​AACR-Novocure Tumor Treating Fields Research Grants

The AACR-Novocure Tumor Treating Fields Research Grants represent a joint effort to promote and support innovative research focused on Tumor Treating Fields (TTFields), which are intermediate frequency, low intensity, alternating electric fields that disrupt cell division in cancer cells. These grants are intended to provide a deeper understanding of the mechanisms of action of this novel anti-cancer treatment modality and to accelerate the development of new treatment strategies to advance therapeutic options for cancer. The research proposed for funding must be focused on the preclinical application of TTFields in cancer and may be basic or translational in nature.

2019 Grantees

Borst_GerbenGerben R. Borst, MD, PhD
Clinician Scientist
The Netherlands Cancer Institute
Amsterdam, The Netherlands
spacerUncovering and exploiting interphase effects of Tumor Treating Fields

Scientific Statement of Research
TTFields are low-intensity intermediate-frequency alternating electric fields used to treat cancer patients. Clinical trials have demonstrated the effectiveness of TTFields in patients with glioblastoma. TTFields may interfere with the proper formation of the mitotic spindle, eventually activating the spindle assembly checkpoint (SAC) and triggering apoptosis. More recent data suggests that TTFields may also affect the replication fork integrity and inhibition of ionizing radiation-induced DNA damage repair. These observations are cell cycle phase dependent, but the impact of TTFields on the cell cycle distribution is not fully elucidated. More research is needed to investigate the underlying mechanism of how TTFields relate to cell cycle changes. This proposed research into the cell cycle effect and the connection to the earlier observations is important for developing novel strategies that will increase the efficacy of TTFields.

Biography
Dr. Borst trained as a radiation oncologist at the Netherlands Cancer Institute. During this training he obtained his PhD and performed a fellowship at the ICR in London, where he studied the effect of radiotherapy induced G2 cell cycle arrest abrogation. After his training he did a postdoctoral fellowship at the Princess Margaret Cancer Centre in Toronto studying the effect of PARP inhibition on radiotherapy outcome. Currently, he treats patients with primary brain tumors and brain metastasis. His research group focuses on combining different modalities to increase the effect of cancer treatment.

Acknowledgement of Support
This AACR-Novocure Tumor Treating Fields Research Grant will allow me to clarify the working mechanism of Tumor Treating Fields. This support is of upmost importance in finding new ways to increase the efficacy of Tumor Treating Fields and thereby improve the treatment outcome for cancer patients.

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Lou_EmilEmil Lou, MD, PhD
Assistant Professor
University of Minnesota
Minneapolis, Minnesota
spacerECM-mimicking platform for testing TTFields and intercellular communication

Scientific Statement of Research
The influence of TTFields on vital processes such as cell-cell communication is unknown. Understanding the role of ultrafine actin-based tunneling nanotubes (TNTs) in bridging cells to allow cell-cell communication and facilitate cancer invasion is continuously evolving. Studies evaluating TNT-driven communication between cells cultured in 3D ECM-mimicking fibrous environments would elucidate factors regulating 1D, 2D, and 3D migrational plasticity. The goal of this project is to determine the effects of TTFields on cell proliferation and TNT-mediated intercellular communication in 3D ECM-mimicking fibrous environments. Identifying effects of TTFields on TNTs in contextually relevant environments provides opportunity for novel therapeutic combinations of TTFields with TNT-targeting drugs.

Biography
After completing undergraduate studies in biochemistry at the State University of New York (SUNY) College at Geneseo, Dr. Lou received his MD and PhD degrees (microbiology and immunology) from SUNY Upstate Medical University in Syracuse, New York in 2004. He performed his residency training in internal medicine at Duke University Medical Center and then subsequently completed his medical oncology and hematology fellowship at the Memorial Sloan Kettering Cancer Center in 2010. He completed an additional fellowship in neuro-oncology at the Preston Robert Tisch Brain Tumor Center at Duke. Dr. Lou, a diplomate of the American Board of Internal Medicine, is board certified in medical oncology and internal medicine. He is also board certified in neuro-oncology through the United Council for Neurologic Subspecialties. He joined the faculty in the Division of Hematology, Oncology and Transplantation in 2011 and is a member of the Masonic Cancer Center, University of Minnesota.

Acknowledgement of Support
I extend my gratitude to the AACR and Novocure for this award. This grant affords the opportunity to bridge cancer cell migrational plasticity with the role of tunneling nanotubes in invasive cancers and to explore TTFields-driven strategies to overcome drug resistance.

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