Dr. Puré, Ph.D. is Professor of Biomedical Sciences, Chair of the Department of Animal Biology and member of the Mari Lowe Center for Comparative Oncology at the School of Veterinary Medicine at the University of Pennsylvania. She is also Professor of Pharmacology, member of the Institute for Translational Medicine and Therapeutics and of the Abramson Cancer Center at Perelman School of Medicine at the University of Pennsylvania. Dr. Puré received her Bachelor's degree from Washington University in St. Louis and her doctoral degree in Biomedical Sciences at the University of Texas Southwestern Medical School in Dallas. She received her postdoctoral training at the Rockefeller University as a Damon Runyon-Walter Winchell Postdoctoral Fellow and a Leukemia Society of America Special Fellow. She became a member of the Rockefeller University Faculty in 1984 and then moved in 1992 to the Wistar Institute. Dr. Puré moved to the University of Pennsylvania in 2013.
Dr. Puré's laboratory studies the cellular and molecular basis of inflammation and fibrosis, with a particular focus on the role of stromal cells and extracellular matrix in the context of chronic inflammatory, fibrotic diseases and cancer. The goal of their research is to define extrinsic tumor suppressor mechanisms of normal tissue that can also drive tumor dormancy, and the extrinsic mechanisms associated with ageing, chronic inflammation, and fibroproliferative diseases that provide a tumor permissive environment and promote metastasis. Their current focus is on relating the biochemical regulation and biomechanical properties of the stromal compartment to its functional impact on homeostasis, inflammatory/fibrotic diseases and cancer. The knowledge gained from these mechanistic studies is being used to develop novel small molecule, nanoparticle-based and immune-based therapeutic approaches targeting the tumor stroma to enhance the efficacy of tumor cell targeted therapies.
Dr. Puré was a PEW Scholar in the Biomedical Sciences and Established Fellow of the American Heart Association. She has received a number of awards including the Distinguished Alumnus Award from the University of Texas Southwestern Medical School, The Stewart J. McCracken Award for Research from the Arthritis Foundation and an Investigator Award from the Asthma and Allergy Foundation of America. Dr. Puré served for many years as the Director of Academic Affairs for the Ludwig Institute for Cancer Research, as Associate Vice President of Academic Affairs of the Wistar Institute and has been a member of the Scientific Advisory Council and Associate Director (since 2003) of the of the Cancer Research Institute since 1989. She has also served on numerous boards including as Assistant Editor of the Journal of Experimental Medicine, the Editorial Board of the Journal of Immunology and as Associate Editor for the Journal of Clinical Investigation. She is currently serving on the American Association for Cancer Research's Program and Education committees and Cancer Immunology Steering Committee.