Karen E. Knudsen, PhD

Karen E. Knudsen, PhD
Professor, Department of Cancer Biology
​Jefferson Medical College of Thomas Jefferson University
Philadelphia,  PA

Dr. Karen E. Knudsen is professor of cancer biology, urology and radiation oncology, at the Thomas Jefferson University and NCI-designated Kimmel Cancer Center in Philadelphia, PA. Dr. Knudsen received her Ph.D., focused on cell cycle checkpoint control, from the University of California at San Diego in 1996. Her postdoctoral studies with Dr. Webster K. Cavenee at the Ludwig Institute for Cancer Research cultivated a program centered on the mechanisms underlying hormone-dependent cell cycle control. Dr. Knudsen was recruited to Thomas Jefferson University in 2007 after a successful career at the University of Cincinnati College of Medicine, where she was a tenured associate professor. Dr. Knudsen now serves as program leader of the Kimmel Cancer Biology of prostate cancer program, and director of the Greater Philadelphia Prostate Cancer Working Group.

Dr. Knudsen’s research interests are dedicated to understanding the mechanisms by which hormone receptor and cell cycle deregulation lead to prostate cancer progression and therapeutic bypass. The overall goal of Dr. Knudsen’s laboratory is to utilize this information for successful development of precision medicine, so as to improve therapeutic outcome and patient care through rational therapy delivery. Her studies identifying tumor suppressor and hormone receptor alterations have uncovered new targets for treating advanced disease, and led to development of biomarker-driven clinical trials.

Dr. Knudsen serves on a multitude of national boards and committees, including those for the American Association for Cancer Research, the Endocrine Society and the Prostate Cancer Foundation. She has been a senior editor for Cancer Research since 2007, is an associate editor for Endocrine-Related Cancer, and sits on the editorial boards of Molecular Cancer Therapeutics, the American Journal of Pathology, Molecular Endocrinology and Oncogene. Dr. Knudsen has received numerous awards for her research, including the Ronald Ross Award for Excellence in hormone-dependent malignancies from the Pacific Rim Breast and Prostate Cancer Research Organization and the Richard E. Weitzman Laureate Award from the Endocrine Society.