Johannes L. Bos, PhD

Johannes L. Bos, PhD
Professor, University Medical Center, Utrecht, Netherlands

​Johannes L. (Hans) Bos, Ph.D., is professor of physiological chemistry at the University Medical Center in Utrecht (Netherlands). Bos started his career in 1975 in the lab of Piet Borst in Amsterdam as a doctoral student working on mitochondrial DNA of yeast. After receiving his doctorate in 1980, he moved to the lab of Alex van der Eb in Leiden, and worked on the characterization of the E1A region of the oncogenic adenovirus 12. In 1984, he started to work on Ras mutations in human tumors. After a sabbatical year in San Francisco in the laboratory of Dr. Frank McCormick, he moved to Utrecht in 1991 to become professor in physiological chemistry and to work on the function of the Ras protein in oncogenic transformation. In 1995 he started to work on the small GTPase Rap1, which is still the main topic in the lab. Major breakthroughs were the discovery of the cAMP-regulated Epac protein in 1998 and the discovery of the essential role of Rap1 in integrin-mediated cell adhesion in 2000 and in E-cadherin-mediated cell junction formation in 2004. More recent highlights are the elucidation of the crystal structure of Epac. Currently, the main focus is on the spatio-temporal control of the Epac-Rap1 module in cell adhesion and the downstream molecular effects.

Bos is currently head of the Department Molecular Cancer Research and chairperson of the Division Biomedical Genetics of the University Medical Center Utrecht. He is director of the PhD and Master's Program, Cancer, Stem Cells and Developmental Biology; director of the Cancer Genomics Centre of the Netherlands Genomics Initiative; and director of the Centre for Biomedical Genetics. He is a member of the Royal Netherlands Academy of Arts and Sciences.