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FINDING CURES TOGETHER<sup>SM</sup>

11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine

Friday, Feb. 8, 2019

Welcome and Keynote Session
6:30-8 p.m.

Cancer genomics: Discovery to clinical translation
Elaine R. Mardis, Nationwide Children's Hospital, Columbus, Ohio

Regulatory T cells in tumor immunity
Shimon Sakaguchi, Osaka University, Osaka, Japan


Opening Reception
8-9:30 p.m.
 

Saturday, Feb. 9, 2019

Continental Breakfast
7-8 a.m.


Plenary Session 1: Tumor Microenvironment
8-9:30 a.m.

Exploiting the biology of exosomes for diagnosis and treatment of cancer
Raghu Kalluri, The University of Texas MD Anderson Cancer Center, Houston, Texas

Role of actin dynamics in cell fate plasticity of microenvironmental cells
Hideyuki Saya, Keio University School of Medicine, Tokyo, Japan

Neutrophil extracellular traps activated during inflammation awaken dormant cancer cells
Mikala Egeblad, Cold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York


Break
9:30-10 a.m.


Plenary Session 2: Cancer Precision Medicine, Prevention, Interception, and Early Detection
10-11:30 a.m.

Non-invasive earlier detection of cancer
Nickolas Papadopoulos, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

Construction of cancer genomic medicine platform in Japan
Hiroyuki Mano, National Cancer Center Research Institute, Tokyo, Japan

Genome-wide analysis of plasma cell-free DNA for cancer detection
Geoffrey R. Oxnard, Dana-Farber Cancer Institute, Boston, Massachusetts


Free Time
11:30 a.m.-4 p.m.


Plenary Session 3: Heterogeneity, Clonal Evolution, and Big Data
4-5:30 p.m.

Clonal dynamics and cellular fitness in cancer to single cell resolution
Samuel Aparicio, British Columbia Cancer Agency, Vancouver, Canada

Strong potential for combinatorial approaches involving TGF-b kinase inhibitor: considerable utility in a wide variety of cancers
Seong-Jin Kim, Seoul National University, Seoul, South Korea

Quantifying clonal evolution through treatment and metastasis
Christina Curtis, Stanford University, Stanford, California


5:30-7:30 p.m.


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Sunday, Feb. 10, 2019

Continental Breakfast
7-8 a.m.


Plenary Session 4: Metabolism
8-9:30 a.m.

Title to be announced
Kei-ichi Nakayama, Kyushu University, Fukuoka, Japan

PI3-kinase and cancer
Lewis C. Cantley, Weill Cornell Medical College, New York- Presbyterian Hospital, New York, New York

NRF2 addiction in cancer cells and its impact on cancer metabolism
Hozumi Motohashi, Tohoku University, Sendai, Japan


Break
9:30-10 a.m.


Plenary Session 5: Epigenetics
10-11:30 a.m.

Precision cancer risk diagnosis based upon epigenomic record of the life
Toshikazu Ushijima, National Cancer Center Research Institute, Tokyo, Japan

Targeting chromatin regulators in cancer
Scott A. Armstrong, Dana-Farber Cancer Institute, Boston, Massachusetts

ATAC-seq analysis reveals epigenomic heterogeneity in breast cancer
Reo Maruyama, Japanese Foundation for Cancer Research Cancer Institute, Tokyo, Japan


Free Time
11:30 a.m.-4 p.m.


Plenary Session 6: Immunotherapy
4-5:30 p.m.

Potent anti-tumor effects of IL-7/CCL19-producing CAR-T cells against solid tumors
Koji Tamada, Yamaguchi University, Yamaguchi, Japan

Genetic alterations involving PD-1 ligands in virus-associated lymphomas
Keisuke Kataoka, National Cancer Center Research Institute, Tokyo, Japan

Additional speaker to be announced


Poster Session B  
5:30-7:30 p.m.


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Monday, Feb. 11, 2019

Continental Breakfast
7-8 a.m.


Plenary Session 7: Microbiome
8-9:30 a.m.

The role of the microbiome in response to cancer therapy
Jennifer A. Wargo, The University of Texas MD Anderson Cancer Center, Houston, Texas

The impact of Helicobacter pylori infection on gastric carcinogenesis
Masanori Hatakeyama, University of Tokyo, Tokyo, Japan

Microbial regulation of tumor elicited inflammation
Sergei Grivennikov, Fox Chase Cancer Center, Philadelphia, Pennsylvania


Break
9:30-10 a.m.


Plenary Session 8: Engineering, Nanotechnology, and Imaging
10-11:30 a.m.

Macrocyclic pseudo-natural peptides for anti-cancer therapies
Hiroaki Suga, University of Tokyo, Tokyo, Japan

Nanomedicines to improve the therapeutic index of precision medicines
Daniel A. Heller, Memorial Sloan Kettering Cancer Center, New York, New York

Application of tissue clearing technology in cancer research
Kei Takahashi, University of Tokyo, Tokyo, Japan


Free Time
11:30 a.m.-4 p.m.


Plenary Session 9: Liquid Biopsy
4-5:30 p.m.

The emerging role of exosome in cancer diagnostic and therapeutics
Takahiro Ochiya, Tokyo Medical University, National Cancer Center Research Institute, Tokyo, Japan

Inactivation of DNA repair to improve immune surveillance and restrict cancer growth
Alberto Bardelli, University of Turin - Candiolo Cancer Institute IRCCS, Candiolo, Italy

A proteome-wide catalog of viable tissue-derived exosomes, toward development of cancer liquid biopsy
Koji Ueda, Japanese Foundation for Cancer Research Cancer Institute, Tokyo, Japan



Poster Session C 
5:30-7:30 p.m.


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Tuesday, Feb. 12, 2019

Continental Breakfast
7-8 a.m.

Plenary Session 10: Drug Resistance
8-9:30 a.m.

Mechanism of the intrinsic resistance and emergence of tolerant cells to osimertinib in EGFR mutated lung cancer
Seiji Yano, Kanazawa University Cancer Research Institute, Kanazawa, Japan

Synthetic lethal approaches to cancer therapy
Alan Ashworth, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, California

Cellular diversity by genetic and non-genetic alteration in cancer induces acquired resistance in NSCLC
Ryohei Katayama, Japanese Foundation for Cancer Research Cancer Institute, Tokyo, Japan


Break
9:30-10 a.m.


Plenary Session 11: Novel Targets and Drug Discovery
10-11:30 a.m.

Chemical strategies for discovering direct inhibitors of K-Ras and other Oncogenic GTPases
Kevan M. Shokat, University of California San Francisco and Howard Hughes Medical Institute, San Francisco, California

Telomere as the starting point of anticancer drug discovery
Hiroyuki Seimiya, Japanese Foundation for Cancer Research Cancer Institute, Tokyo, Japan

Structure and function of mammalian SWI/SNF chromatin remodeling complexes in human cancer
Cigall Kadoch, Dana-Farber Cancer Institute, Boston, Massachusetts


Free Time
11:30 a.m.-3:30 p.m.


Plenary Session 12: Clinical Research and Clinical Trials
3:30-5:30 p.m.

Drug repurposing for diffuse large B-cell lymphoma
Riccardo Dalla-Favera, Columbia University Institute for Cancer Genetics, New York, New York

Metabolic regulation of stemness in hematopoietic malignancy
Atsushi Hirao, Kanazawa University Cancer Research Institute, Kanazawa, Japan

Targeting oncogene dependencies in metastatic breast cancer: A clinical and translational perspective
Dejan Juric, Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Phase II clinical trial of oncolytic herpes virus G47Δ in patients with glioblastoma
Tomoki Todo, University of Tokyo, Tokyo, Japan


Poster Session D  
5:30-7:30 p.m.

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