September 28 - Oct 1, 2018
Marriott New York Brooklyn Bridge
New York, New York, USA
Abstract submission deadline: Wednesday, July 11
Advance registration deadline: Monday, August 13
Friday, Sept. 28
Saturday, Sept. 29
Sunday, Sept. 30
Monday, Oct. 1
Friday, Sept. 28
Welcome and Opening Keynote Lecture
Keynote LectureLactate exchange promotes oxidative stress resistance and melanoma metastasis Sean J. Morrison, UT Southwestern, Dallas, Texas
Plenary Session 1: Influence of Metabolism on Metastasis / ProgressionSession Chair: Eileen P. White, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey6-7:30 p.m.
Targeting cancer-specific vulnerabilitiesRonald A. DePinho, The University of Texas MD Anderson Cancer Center, Houston, Texas
Autophagy and cancer Eileen P. White
A new role for glycogen in metastasis*
Ernst Lengyel, University of Chicago, Chicago, Illinois
Using clear cell like-RenCa and papillary like-RenCa models of kidney cancer to study metabolic influences on the microenvironment and metastasis*
Bradley Reinfeld, Vanderbilt University School of Medicine, Nashville, Tennessee
Welcome Reception7:30-9:30 p.m.
Linking oncogenic signaling to anabolic cell growth Brendan D. Manning, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
Uncovering metabolic bottlenecks in lung cancerThales Papagiannakopoulos, NYU School of Medicine, New York, New York
Characterization of a novel AICARFT inhibitor that potently elevates ZMP and has antitumor activity in murine models* Harold Brooks, Eli Lilly and Company, Indianapolis, Indiana
Plenary Session 3: Redox MetabolismSession Chair: Karen H. Vousden, The Francis Crick Institute, London, United Kingdom 10:45 a.m.-1 p.m.
Oxygen and iron: Friends or foes
Richard Possemato, NYU School of Medicine, New York, New York
Folate metabolism: Potential vulnerabilities in cancers
Lewis C. Cantley, Weill Cornell Medical College, New York, New York
p53 pathways and cancer cell metabolismKaren H. Vousden
Understanding natural tolerance to cancer-causing mutations: Imaging homeostatic equilibrium of oncogenic mutant clones in phenotypically normal tissue of live mice* Anupama Hemalatha, Yale School of Medicine, New Haven, Connecticut
Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion* Isaac Harris, Ludwig Cancer Center, Harvard Medical School, Boston, Massachusetts
Poster Session A / Lunch1-3:30 p.m.
Plenary Session 4: Circadian and Organismal MetabolismSession Chair: Joshua D. Rabinowitz, Princeton University, Princeton, New Jersey3:30-5 p.m.
Metabolic exchange between tissues (and tumors)Joshua D. Rabinowitz
Convergence of MYC, metabolism, the circadian clock and immunityChi Van Dang, The Wistar Institute, Philadelphia, Pennsylvania
Cellular mechanism of insulin resistance: Implications for obesity, type 2 diabetes and cancerGerald I. Shulman, Yale School of Medicine, New Haven, Connecticut
Dinner on Own5 p.m.
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Sunday, Sept. 30Continental Breakfast7-8 a.m.
Plenary Session 5: Cancer Heterogeneity and MicroenvironmentSession Chair: Trudy Oliver, Huntsman Cancer Institute, Salt Lake City, Utah8-10:15 a.m.
Identifying metabolic dependencies in pancreatic cancerAlec C. Kimmelman, NYU Langone Health, New York, New York
Metabolic complexity in cancer cells and tumorsRalph J. DeBerardinis, UT Southwestern, Dallas, Texas
MYC drives unique metabolic vulnerabilities in small-cell lung cancerTrudy Oliver
Regulation of nutrient stress-induced macropinocytosis in pancreatic cancer*Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California
A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression*
Mara Sherman, Oregon Health and Science University, Portland, Oregon
A regulatory multienzyme complex for glucose metabolism and its contributions to the Warburg effect in single cancer cells*
Songon An, University of Maryland, Baltimore County, Baltimore, Maryland
Plenary Session 6: Metabolism and DevelopmentSession Chair: Aimee L. Edinger, University of California, Irvine, Irvine, California10:45 a.m.-12:30 p.m.
Metabolic adaptation in hemopoietic malignancies
Tak W. Mak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada
Mitochondria, metabolism and cellular decisions Jared P. Rutter, University of Utah, Salt Lake City, Utah
Nutrient scavenging via macropinocytosis Aimee L. Edinger
The p53-p21 axis suppresses metabolic stress-induced ferroptosis*Amy Tarangelo, Stanford University, Stanford, California
Lunch on Own12:30-2:30 p.m.
Plenary Session 7: ImmunometabolismSession Chair: Janelle Ayres, Salk Institute for Biological Studies, La Jolla, California2:30-4:30 p.m.
Examining T-cell metabolic reprogramming in vivoRussell Jones, Van Andel Institute, Grand Rapids, Michigan
Host-microbiota interactions and metabolismJanelle Ayres
Mitochondria control adaptive immunity
Navdeep S. Chandel, Northwestern Medicine, Chicago, Illinois
Nutrient-dependent activation of mTORC1 by RRAGC mutations enhance germinal center activation and drive follicular lymphoma*Ana Ortega-Molina, Spanish National Cancer Research Center, Madrid, Spain
PD-L1 is upregulated in the adipose tissue of tumor-bearing mice*Max Heckler, Dana Farber Cancer Institute, Boston, Massachusetts
Poster Session B / Reception 4:30-7 p.m.
Monday, Oct. 1Continental Breakfast7-8 a.m.
Closing Keynote Lecture8-9 a.m.
The role of metabolites in regulating cellular differentiation
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, New York, New York
Plenary Session 8: New Metabolic PathwaysSession Chair: Ayelet Erez, Weizmann Institute of Science, Rehovot, Israel9-10:45 a.m.
Metabolic limitations of tumor growthMatthew G. Vander Heiden, Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts
Dual functions of metabolic enzymesM. Celeste Simon, University of Pennsylvania, Philadelphia, Pennsylvania
The role of amino acid metabolism in carcinogenesisAyelet Erez
PKM2-mediated upregulation of serine synthesis pathway enables leukemic cells to proliferate in fructose-rich culture conditions*Sangmoo Jeong, Memorial Sloan Kettering Cancer Center, New York, New York
Plenary Session 9: Metabolism and EpigeneticsSession Chair: Lydia Finley, Memorial Sloan Kettering Cancer Center, New York, New York11:00 a.m.-12:45 p.m.
Metabolic coordination of tumor suppressionLydia Finley
Non-oncogene addiction to SIRT3 plays a critical role in lymphomagenesisAri M. Melnick, Weill Cornell Medical College, New York, New York
Acetyl-CoA metabolism in chromatin regulation and tumorigenesisKathryn E. Wellen, University of Pennsylvania, Philadelphia, Pennsylvania
Closing Remarks12:45 p.m.
*Short talk from proffered abstract
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