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FINDING CURES TOGETHER<sup>SM</sup>

Metabolism and Cancer

​Program   

Friday, Sept. 28

Saturday, Sept. 29

Sunday, Sept. 30

Monday, Oct. 1

Friday, Sept. 28

Welcome and Opening Keynote Lecture 
5-6 p.m.

Keynote Lecture
Lactate exchange promotes oxidative stress resistance and melanoma metastasis
Sean J. Morrison, UT Southwestern, Dallas, Texas

Plenary Session 1: Influence of Metabolism on Metastasis / Progression
Session Chair: Eileen P. White, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
6-7:30 p.m.

Targeting cancer-specific vulnerabilities
Ronald A. DePinho, The University of Texas MD Anderson Cancer Center, Houston, Texas

Autophagy and cancer
Eileen P. White

A new role for glycogen in metastasis*
Ernst Lengyel, University of Chicago, Chicago, Illinois

Using clear cell like-RenCa and papillary like-RenCa models of kidney cancer to study metabolic influences on the microenvironment and metastasis*
Bradley Reinfeld, Vanderbilt University School of Medicine, Nashville, Tennessee


Welcome Reception
7:30-9:30 p.m.

 
Saturday, Sept. 29

Continental Breakfast
7-8 a.m.


Plenary Session 2: Therapeutic Targets
Session Chair: M. Celeste Simon, University of Pennsylvania, Philadelphia, Pennsylvania
8-10:15 a.m.

Precision medicine in cancer metabolism
Kevin Marks, Agios Pharmaceuticals, Cambridge, Massachusetts

Linking oncogenic signaling to anabolic cell growth
Brendan D. Manning, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 

Uncovering metabolic bottlenecks in lung cancer
Thales Papagiannakopoulos, NYU School of Medicine, New York, New York 

Therapeutic effects and metabolic rewiring upon glutaminase loss in T-ALL*
Daniel Herranz, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress*
Peter Tsvetkov, Broad Institute of Harvard and MIT, Cambridge, Massachusetts

Characterization of a novel AICARFT inhibitor that potently elevates ZMP and has antitumor activity in murine models* Harold Brooks, Eli Lilly and Company, Indianapolis, Indiana


Break
10:15-10:45 a.m.


Plenary Session 3: Redox Metabolism
Session Chair: Karen H. Vousden, The Francis Crick Institute, London, United Kingdom
10:45 a.m.-1 p.m.

Oxygen and iron: Friends or foes
Richard Possemato, NYU School of Medicine, New York, New York

Folate metabolism: Potential vulnerabilities in cancers
Lewis C. Cantley, Weill Cornell Medical College, New York, New York

p53 pathways and cancer cell metabolism
Karen H. Vousden

Understanding natural tolerance to cancer-causing mutations: Imaging homeostatic equilibrium of oncogenic mutant clones in phenotypically normal tissue of live mice*
Anupama Hemalatha, Yale School of Medicine, New Haven, Connecticut 

Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion*
Isaac Harris, Ludwig Cancer Center, Harvard Medical School, Boston, Massachusetts 

Cystine-glutamate antiporter xCT deficiency suppresses tumor growth without impairing antitumor immunity*
Michael Arensman, Pfizer, Pearl River, New York


Poster Session A / Lunch
1-3:30 p.m.

Plenary Session 4: Circadian and Organismal Metabolism
Session Chair: Joshua D. Rabinowitz, Princeton University, Princeton, New Jersey
3:30-5 p.m.

Metabolic exchange between tissues (and tumors)
Joshua D. Rabinowitz

Convergence of MYC, metabolism, the circadian clock and immunity
Chi Van Dang, The Wistar Institute, Philadelphia, Pennsylvania

Cellular mechanism of insulin resistance: Implications for obesity, type 2 diabetes and cancer
Gerald I. Shulman, Yale School of Medicine, New Haven, Connecticut


Dinner on Own
5 p.m.


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Sunday, Sept. 30

Continental Breakfast
7-8 a.m.

Plenary Session 5: Cancer Heterogeneity and Microenvironment
Session Chair: Trudy Oliver, Huntsman Cancer Institute, Salt Lake City, Utah
8-10:15 a.m.

Identifying metabolic dependencies in pancreatic cancer
Alec C. Kimmelman, NYU Langone Health, New York, New York

Metabolic complexity in cancer cells and tumors
Ralph J. DeBerardinis, UT Southwestern, Dallas, Texas 

MYC drives unique metabolic vulnerabilities in small-cell lung cancer
Trudy Oliver

Regulation of nutrient stress-induced macropinocytosis in pancreatic cancer*
Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression*
Mara Sherman, Oregon Health and Science University, Portland, Oregon 

A regulatory multienzyme complex for glucose metabolism and its contributions to the Warburg effect in single cancer cells*
Songon An, University of Maryland, Baltimore County, Baltimore, Maryland


Break
10:15-10:45 a.m.


Plenary Session 6: Metabolism and Development
Session Chair: Aimee L. Edinger, University of California, Irvine, Irvine, California
10:45 a.m.-12:30 p.m.

Metabolic adaptation in hemopoietic malignancies
Tak W. Mak, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Mitochondria, metabolism and cellular decisions 
Jared P. Rutter, University of Utah, Salt Lake City, Utah

Nutrient scavenging via macropinocytosis  
Aimee L. Edinger

The p53-p21 axis suppresses metabolic stress-induced ferroptosis*
Amy Tarangelo, Stanford University, Stanford, California


Lunch on Own
12:30-2:30 p.m.


Plenary Session 7: Immunometabolism
Session Chair: Janelle Ayres, Salk Institute for Biological Studies, La Jolla, California
2:30-4:30 p.m.

Examining T-cell metabolic reprogramming in vivo
Russell Jones, Van Andel Institute, Grand Rapids, Michigan

Host-microbiota interactions and metabolism
Janelle Ayres

Mitochondria control adaptive immunity
Navdeep S. Chandel, Northwestern Medicine, Chicago, Illinois 

Nutrient-dependent activation of mTORC1 by RRAGC mutations enhance germinal center activation and drive follicular lymphoma*
Ana Ortega-Molina, Spanish National Cancer Research Center, Madrid, Spain 

PD-L1 is upregulated in the adipose tissue of tumor-bearing mice*
Max Heckler, Dana Farber Cancer Institute, Boston, Massachusetts 


Poster Session B / Reception 
4:30-7 p.m.


Monday, Oct. 1

Continental Breakfast
7-8 a.m.

Closing Keynote Lecture
8-9 a.m.

The role of metabolites in regulating cellular differentiation
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, New York, New York


Plenary Session 8: New Metabolic Pathways
Session Chair: Ayelet Erez, Weizmann Institute of Science, Rehovot, Israel
9-10:45 a.m.

Metabolic limitations of tumor growth
Matthew G. Vander Heiden, Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 

Dual functions of metabolic enzymes
M. Celeste Simon, University of Pennsylvania, Philadelphia, Pennsylvania 

The role of amino acid metabolism in carcinogenesis
Ayelet Erez

PKM2-mediated upregulation of serine synthesis pathway enables leukemic cells to proliferate in fructose-rich culture conditions*
Sangmoo Jeong, Memorial Sloan Kettering Cancer Center, New York, New York


Break
10:45-11 a.m.

Plenary Session 9: Metabolism and Epigenetics
Session Chair: Lydia Finley, Memorial Sloan Kettering Cancer Center, New York, New York
11:00 a.m.-12:45 p.m.

Metabolic coordination of tumor suppression
Lydia Finley

Non-oncogene addiction to SIRT3 plays a critical role in lymphomagenesis
Ari M. Melnick, Weill Cornell Medical College, New York, New York

Acetyl-CoA metabolism in chromatin regulation and tumorigenesis
Kathryn E. Wellen, University of Pennsylvania, Philadelphia, Pennsylvania

Alpha-ketoglutarate contributes to p53-mediated cell fate changes during tumor suppression*
Jossie J. Yashinskie, Memorial Sloan Kettering Cancer Center, New York, New York

Closing Remarks
12:45 p.m.


*Short talk from proffered abstract 


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