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FINDING CURES TOGETHER<sup>SM</sup>

Evolutionary Dynamics in Carcinogenesis and Response to Therapy

Program 

Thursday, March 12, 2020

Friday, March 13, 2020

Saturday, March 14, 2020

Sunday, March 15, 2020


Thursday, March 12

Welcome and Opening Keynote Addresses
6:30-8 p.m.

Welcome

Opening Keynote Addresses

Ecology and evolution in control and cure of metastatic cancers
Robert A. Gatenby, Moffit Cancer Center, Tampa, Florida

Title to be announced
Charlie Swanton, The Francis Crick Institute and UCL Cancer Institute, London, United Kingdom


Opening Reception

8-10 p.m.

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Friday, March 13

Continental Breakfast
7-8 a.m.


Plenary Session 1
: Longitudinal Dissection of Resistance Evolution
Session Chair: Marco Gerlinger, The Institute of Cancer Research, London, United Kingdom
8-10 a.m.

Title to be announced
Marco Gerlinger

Investigating clonal dynamics and evolution of metabolic vulnerabilities in chemoresistant triple negative breast cancer*
Gloria Echeverria, Baylor College of Medicine, Houston, Texas

Novel cancer therapeutic approaches
Jeffrey A. Engelman, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts

Longitudinal molecular trajectories of diffuse glioma in adults*
Floris Barthel, The Jackson Laboratory, Farmington, Connecticut

Title to be announced
Trever G. Bivona, University of California San Francisco, San Francisco, California


Break

10-10:30 a.m.


Panel Discussion: Genetic, Epigenetic, and Functional Heterogeneity in Cancer: Which One(s) Can We Call Evolution?
Panel Moderator: Robert Gillies, Moffitt Cancer Center, Tampa, Florida
10:30-11:30 a.m.

Panelists:
Andrew Feinberg, Johns Hopkins School of Medicine, Baltimore, Maryland
Robert Gatenby, Moffit Cancer Center, Tampa, Florida
Kornelia Polyak, Dana-Farber Cancer Institute, Boston, Massachusetts
Charlie Swanton, The Francis Crick Institute and UCL Cancer Institute, London, United Kingdom


Poster Session A / Lunch

11:30 a.m.-2 p.m.


Plenary Session 2: Clonal Evolution Part I
Session Chair: Robert J. Gillies, Moffitt Cancer Center, Tampa, Florida
2-4 p.m.

Somatic mutation and clonal expansions in human tissues
Iñigo Martincorena, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Stem cell dynamics in developing and established cancers in the gut
Louis Vermeulen, Academic Medical Center, Amsterdam, Netherlands

In cancer as in real estate, location matters: The role of extrachromosomal oncogene amplification in cancer
Paul S. Mischel, University of California San Diego, San Diego, California

Selecting for a glycolytic phenotype
Robert J. Gillies


Break
4-4:15 p.m.

Plenary Session 3: Generation of Genomic and Epigenomic Diversity
Session Chair: Rong Li, Johns Hopkins University, Baltimore, Maryland
4:15-6:15 p.m.

Natural selection of cancer cells in a stochastic epigenetic landscape
Andrew P. Feinberg, Johns Hopkins School of Medicine, Baltimore, Maryland

Genomic transcriptional diversity induced by UV exposure: molecular drivers of squamous cell carcinoma development*
Leticia Tordesillas, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo
Reuben S. Harris, University of Minnesota, Minneapolis Minnesota

Epigenetically regulated DNA rereplication as a precursor to inherited gene amplification*
Joshua Black, University of Colorado, Denver, Colorado

The DNA damageome:  A cancer evolvability protein network Discovered in E. coli
Susan Rosenberg, Baylor College of Medicine, Houston, Texas


Evening Off / Dinner on Own

6:15 p.m.

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Saturday, March 14

Continental Breakfast
7-8 a.m.


Plenary Session 4: Microenvironmental Selection
Session Chair: Kornelia Polyak, Dana-Farber Cancer Institute, Boston, Massachusetts
8-10 a.m.

Ageing, tissue ecology and the evolution of cancer within us
James V. DeGregori, University of Colorado, Aurora, Colorado

Breast tumor evolution: the role of the microenvironment
Kornelia Polyak

Understanding how age-dependent inflammation can lead to oncogenic adaptation in lung cancer*
Catherine Danis, University of Colorado, Denver, Colorado

Cancer evolution in the lens of single cell multi-omics
Dan A. Landau, Meyer Cancer Institute, Cornell University, New York, New York


Break
10-10:30 a.m.


Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence Part I
Session Chair: Andriy Marusyk, Moffitt Cancer Center, Tampa, Florida
10:30 a.m.-12:30 p.m.

Title to be announced
Michael T. Hemann, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts

Title to be announced
Max Diehn, Stanford University, School of Medicine, Stanford, California

Multimodal integration of scRNA-seq and longitudinal treatment-response data into a mathematical model of chemotherapeutic resistance dynamics*
Kaitlyn Johnson, The University of Texas at Austin, Austin, Texas

Resistance to targeted therapies as a gradual, multifactorial adaptation to inhibitor specific selective pressures
Andriy Marusyk


Lunch on Own

12:30-2 p.m.


Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence Part II
Session Chair: Ivana Bozic, University of Washington, Seattle, Washington
2-5 p.m.

Title to be announced
Ira Mellman, Genentech, Inc., South San Francisco, California

Title to be announced
Jennifer Wargo, The Unviersity of Texas MD Anderson Cancer Center, Houston, Texas


Break

3:15-3:30 p.m.


Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence Part II (continued)

Emergent cellular ecosystems in melanoma revealed by single cell analysis
Arjun Raj, University of Pennsylvania, Philadelphia, Pennsylvania

Heterogeneous clonal dynamics of leukemia progression and chemotherapy response in patient-derived xenograft models*
Rong Lu, University of Southern California, Los Angeles, California

Evolutionary dynamics of cancer and its response to therapy
Ivana Bozic

Extensive subclonal mutational diversity in human colorectal cancer (CRC) and its significance*
Robert Beckman, Georgetown University, Washington D.C.


Poster Session B / Reception

5-7 p.m.


Dinner on Own

7 p.m.


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Sunday, March 15

Continental Breakfast
7-8 a.m.


Plenary Session 6: Evolutionary Guided (Adaptive) Therapy to Prevent Emergence of Resistance
Session Chair: Carlo C. Maley, Arizona State University, Tempe, Arizona
8-10 a.m.

Karyotype heterogeneity driving rapid evolutionary adaptation
Rong Li, Johns Hopkins University, Baltimore, Maryland

Adaptive mutability of colorectal cancer in response to targeted therapies
Alberto Bardelli, Candiolo Cancer Institute IRCCS, University of Turin, Italy 

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap*
Kevin Lin, Duke University School of Medicine, Durham, North Carolina

Explorations in adaptive therapy
Carlo C. Maley


Break

10-10:30 a.m.


Plenary Session 7: Clonal Evolution Part II

Session Chair: Christina Curtis, Stanford University School of Medicine, Stanford, California
10:30 a.m.-12:30 p.m.

Title to be announced
Andrea Sottoriva, The Institute of Cancer Research, London, United Kingdom (ICR)

Opposing evolutionary pressures drive clonal evolution and health outcomes in the aging blood system*
Kimberly Skead, Ontario Institute for Cancer Research, Toronto, Canada

Title to be announced
Nicholas E. Navin, The University of Texas MD Anderson Cancer Center, Houston, Texas

The landscape of somatic mutations in normal human cells*
Luiza Moore, Wellcome Sanger Institute, Cambridge, United Kingdom

Towards quantifying and forecasting tumor evolution
Christina Curtis


Closing Remarks

12:30 p.m. 


*Short talk from proffered abstracts


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