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FINDING CURES TOGETHER<sup>SM</sup>

The Evolving Landscape of Cancer Modeling

Program 

Monday, March 2

Tuesday, March 3

Wednesday, March 4

Thursday, March 5

Monday, March 2

Welcome and Keynote Lectures

5-7 p.m.

Targeting tumor biological mechanisms in mouse models of cancer
Ronald A. DePinho, The University of Texas MD Anderson Cancer Center, Houston, Texas

Title to be announced
Toshiro Sato, Keio University, Tokyo Japan


Opening Reception
7-9 p.m.


Tuesday, March 3

Continental Breakfast
7-8 a.m.

Plenary Session 1: Lineage Plasticity, Stem Cells, and Developmental Pathways
8-10 a.m.

Neuroendocrine differentiation in prostate development and cancer
Michael M. Shen, Columbia University, New York, New York

Stem cells: Coping with stress and cancer
Elaine Fuchs, Rockefeller University, New York, New York

Notch signaling and intra-tumoral heterogeneity in small cell lung cancer
Julien Sage, Stanford University, Stanford, California


Break
10-10:30 a.m.


Plenary Session 2: Modeling the Immune Response and the Tumor Microenvironment
10:30 a.m.-12:30 p.m.

The tissue-specific microenvironment in primary tumors and metastases
Zena Werb, University of California San Francisco, San Francisco, California

Title to be announced
Calvin J. Kuo, Stanford University, Stanford, California

Title to be announced
Sunil R. Hingorani, Fred Hutchinson Cancer Research Center, Seattle, Washington


Lunch on Own
12:30-2:30 p.m.


Plenary Session 3: Modeling Drug Sensitivity and Adaptive Response
2:30-4:30 p.m.

Pharmacogenomic screens for therapeutic biomarker discovery
Mathew Garnett, Wellcome Sanger Institute, Cambridge, England

GEM tumor models to evaluate therapeutic activity and toxicity of potential cancer targets
Mariano Barbacid, CNIO, Madrid, Spain

Modeling sensitivity and resistance to systemic therapies in lung cancer
Katerina A. Politi, Yale University, New Haven, Connecticut


Poster Session A / Reception
4:30-7 p.m.


Wednesday, March 4

Continental Breakfast
7-8 a.m.


Plenary Session 4: Modeling Tumor Evolution
8-10 a.m.

From mouse to man: Dissecting cancer mechanisms using mouse models
Cory Abate-Shen, Columbia University, New York, New York

Title to be announced
Yibin Kang, Princeton University, Princeton, New Jersey

Deconstructing paths of pancreatic cancer development
Laura D. Attardi, Stanford University, Stanford, California


Break

10-10:30 a.m.


Model Fidelity Forum
10:30 a.m.-12:00 p.m.

Embracing complexity: Why we need to change how we use mouse models to understand human cancer
Carol J. Bult, The Jackson Laboratory, Bar Harbor, Maine

The International Human Cancer Models Initiative is generating models annotated with clinical and molecular data
Daniela S. Gerhard, National Cancer Institute, Bethesda, Maryland

Second Keynote Lecture
12-1 p.m.

Title to be announced
William C. Hahn, Dana-Farber Cancer Institute, Boston, Massachusetts


Poster Session B / Lunch
1-3:30 p.m.


Plenary Session 5: From Models to the Clinic
3:30-5:30 p.m.

Title to be announced
Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands

Title to be announced
Pier Paolo Pandolfi, Dana-Farber Cancer Institute, Boston, Massachusetts

Targeting autophagy in cancer
Eileen P. White, Rutgers University, New Brunswick, New Jersey


Dinner on Own
5:30 p.m.


Thursday, March 5

Continental Breakfast
7-8 a.m.

Plenary Session 6: Systems Approaches to Interrogating Data from Models
8-10 a.m.

Systems approach to rational combination therapy
Gordon B. Mills, Oregon Health and Science University Knight Cancer Institute, Portland, Oregon

Single-cell-resolution lineage tracing of tumors in a mouse xenograft model reveals rapid and multidirectional metastasis
Jonathan S. Weissman, University of California San Francisco, San Francisco, California

Title to be announced
Andrea Califano, Columbia University, New York, New York


Break
10-10:30 a.m.

Plenary Session 7: Looking to the Future of Cancer Modeling
10:30 a.m.-12:30 p.m.

Interrogating the cancer genome at base pair resolution
Lukas E. Dow, Weill Cornell Medicine, New York, New York 

In vivo and ex vivo chromosome engineering
Andrea Ventura, Memorial Sloan Kettering Cancer Center, New York, New York 

Multiplexed functional cancer genomics  
Monte M. Winslow, Stanford University, Stanford, California  

Title to be announced
Tyler Jacks, The Koch Institute of MIT, Cambridge, Massachusetts

Closing Remarks
12:30 p.m.

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