Ronald A. DePinho, MD

Ronald A. DePinho, MD
​President, University of Texas MD Anderson Cancer Center, Houston, Texas

Ronald A. DePinho, MD | Class of 2015

A widely recognized authority on cancer, Dr. DePinho has made important scientific discoveries that have transformed the understanding of fundamental mechanisms responsible for aging and the onset of degenerative diseases and cancer. He led efforts to establish inducible murine cancer models and sophisticated models of melanoma and other cancers that unraveled the genetic underpinnings of carcinogenesis, explored physiological host-tumor interactions, and identified prognostic biomarkers for prostate cancer and targets for drugs in clinical trials.

Dr. DePinho coined the concept of “tumor maintenance,” whereby a cancer-initiating oncogene may remain active throughout tumorigenesis, despite the presence of additional acquired mutations, a finding that has proved essential for the development of cancer therapeutics. Similarly, his concept of collateral lethality reveals cancer-specific therapeutic vulnerabilities. He also utilized mouse models to elucidate the function of telomeres and how their dysfunction correlates with cancer risk. He demonstrated that impaired DNA damage checkpoint signaling, coupled with telomere dysfunction, drives epithelial carcinogenesis and increased rates of chromosomal abnormalities capable of contributing to cancer onset. Dr. DePinho was the first to prove that chronic degenerative diseases can be a direct result of telomere dysfunction and that telomerase activation may prove efficacious in treating chronic conditions and some cancers. He also elucidated a core pathway of aging by linking genotoxic stress, oxidative injury and mitochondrial dysfunction, and by showing that aging is a reversible process.

He demonstrated the tumor suppressive roles of the INK4a/ARF locus, linking ARF to regulation of the MDM2-p53 axis and the anti-oncologic role of Mxi1 that antagonizes Myc via the Sin3/HDAC co-repressor complex, thereby establishing a link between sequence-specific transcription factors, chromatin regulation, and the ability of p53 to sense inappropriate cell cycle entry and activate the apoptotic checkpoint. He also launched the Moon Shots Program, a goal-oriented initiative driven by large teams with enabling technology and resources, which is leading to practice-changing cancer care.

Career Highlights

​2012  American Italian Cancer Foundation Prize for Scientific Excellence in Medicine
2012  Elected Member, National Academy of Sciences, Washington, DC
2010  Elected Fellow, American Academy of Arts and Sciences
2009  Albert Szent-Györgyi Prize for Progress in Cancer Research
2007  Helsinki Medal
2004  Elected Member, Institute of Medicine
2003  AACR-G.H.A. Clowes Memorial Award
2003  Senior Scholar Award, Ellison Medical Foundation
2002  Stanley J. Korsmeyer Award, American Society for Clinical Investigation
2001-2004  Board of Directors, AACR
2000  Clair W. & Richard P. Morse Research Award, Dana-Farber Cancer Institute
2000  Kirsch Senior Investigator Award
1995  Irma T. Hirschl Career Scientist Award
1993  Melini Award for Excellence in Biomedical Research
1981  MD, Albert Einstein College of Medicine