Younger Individuals May Have the Highest Risk of Presenting with Distant-stage Colorectal Cancer
Risk may be greatest among young Black and Hispanic subgroups PHILADELPHIA – Individuals between 20 and 39 years old...
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Combination Therapies May Improve Outcomes Due to Independent, Rather Than Synergistic or Additive, Drug Action
Findings have implications for future cancer clinical trial design involving immune checkpoint inhibitors PHILADELPHIA – Independent drug action, not...
Survival Rate of Adult Patients With Relapsed Acute Lymphoblastic Leukemia After Hematopoietic Cell Transplantation Has Steadily Increased Over the Past Two Decades
Study reports progressive improvement in the outcomes of patients carrying the Philadelphia chromosome PHILADELPHIA – For patients with acute...
The Inaugural WHO Classification of Childhood Tumors Will Provide a Unified, Updated Resource for the Diagnosis of Pediatric Cancers
Resource reflects transition from a mostly microscopy-driven to a molecularly driven classification system PHILADELPHIA – The first classification of...
Investigational Therapy Pyrotinib with Chemotherapy May Improve Outcomes in Patients with Pretreated HER2-positive Breast Cancer
SAN ANTONIO – Among patients with previously treated HER2-positive metastatic breast cancer, those who received pyrotinib plus capecitabine had...
Breast Cancer Patients with Estrogen Receptor Mutations May Benefit From Early Switch to Fulvestrant/Palbociclib
Mutations were detected via circulating tumor DNA before disease progression in patients treated with an aromatase inhibitor/palbociclib for hormone...
Tamoxifen May Boost PI3K Signaling to Increase Uterine Cancer Risk in Patients With Breast Cancer
Concurrent treatment with PI3K pathway inhibitors may benefit at-risk patients SAN ANTONIO – Uterine cancers that developed in patients...
Black and White Women Who Received Neoadjuvant Therapy Were Equally Likely to Have Pathologic Complete Response
Tumor biology, not race, was a more significant factor in predicting response to clinical trial treatment SAN ANTONIO – Analysis...
Black Women are More Likely to Develop Lymphedema Following Breast Cancer Treatment than White Women
SAN ANTONIO – Black women experienced higher rates of breast cancer-related lymphedema than white women, and Black race was...
Elacestrant May Improve Outcomes for Patients Whose Metastatic Breast Cancers Progressed on Prior Endocrine Therapy
Elacestrant is the first oral selective estrogen receptor degrader to show clinical benefit over standard of care in a...