DNA repair; inherited cancer syndromes; molecular signaling pathways which regulate the DNA damage response in mammalian cells; Fanconi anemia; FANCA, FANCC, and FANCG proteins; identification and cloning of other proteins in the FA complex and the biochemical assessment of the function of the nuclear FA complex; gene therapy.
Director, Center for DNA Damage and Repair; Director, Susan F. Smith Center for Women’s Cancers; and Member, Department of Medical Oncology, Dana-Farber Cancer Institute; The Fuller-American Cancer Society Professor, Department of Radiation Oncology, and Professor of Pediatrics, Harvard Medical School; Member, Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts; Associate Member and Coleader, BRCA1 Team, Broad Institute, Cambridge, Massachusetts.
Associate Professor (1995-2000), Assistant Professor (1991-1994), and Instructor (1988-1990), Pediatrics; Assistant Professor, Cell and Developmental Biology (1990-1994), Harvard Medical School, Boston, Massachusetts.
Research Fellow, Pediatrics, Dana-Farber Cancer Institute (1986-1988), Boston, Massachusetts; Clinical Fellow, Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute (1986-1988), Boston, Massachusetts; Resident (1984-1986) and Intern (1983-1984), Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
Selected AACR Service, Honors, and Awards
Cochair, AACR Advances in Ovarian Cancer Research Conference (2019); Chair, AACR Gynecological Cancer Research Grants Scientific Review Committee (2017-2018); Speaker, New Frontiers in Cancer Research Conference, Cape Town, South Africa (2017); Speaker, AACR-LACOG Translational Cancer Medicine Conference, São Paulo, Brazil (2017); Member, Stand Up To Cancer Catalyst™ Research, Genentech-Supported Projects Steering Committee (2016); Speaker, Special Conference, DNA Repair: “Tumor Development and Therapeutic Response,” Montreal, Quebec, Canada (2016); Keynote Speaker, AACR Advances in Ovarian Cancer Research: “Exploiting Vulnerabilities” (2015); Member, Joint Scientific Advisory Committee, AACR/Stand Up To Cancer/St. Baldrick’s Foundation (2013-present); Scientific Editor, Cancer Discovery (2013-present); Recipient, AACR G.H.A. Clowes Memorial Award (2012); Member, Special Conferences Committee (2011-2013); Faculty, AACR Molecular Biology in Clinical Oncology Workshop (2005-2012).
Selected Non-AACR Service, Honors, and Awards
Recipient, Fanconi Anemia Research Fund Lifetime Achievement Award (2019); Recipient, Ernest Beutler Lecture and Prize, American Society of Hematology (ASH) Annual Meeting (2018); Elected Member, National Academy of Medicine (2017); Member, Ovarian Cancer Research Fund Alliance Scientific Advisory Board (2017-present); Leader, Stand Up To Cancer-Ovarian Cancer Research Fund-Ovarian Cancer National Alliance-National Ovarian Cancer Coalition Dream Team (2015-present); Leader, NCI-CTEP Drug Discovery Team (2015); Keynote Speaker, International Society of Experimental Hematology Symposium, Kyoto, Japan (2015); Member, NCI Board of Scientific Counselors for Basic Sciences (2014-present); Plenary Speaker, European Hematology Association Congress, Milan, Italy (2014); Plenary Speaker, ASH Annual Meeting (2014); Plenary Speaker, San Antonio Breast Cancer Symposium (2014); Recipient, Annual Peter H. Levine, MD Lecture, University of Massachusetts Medical School (2013); Elected Fellow, American Association for the Advancement of Science (2012); Keynote Address, International Workshop on Radiation Damage to DNA (2010); Recipient, Merit Award, National Institutes of Health, NHLBI (2009); Recipient, 9th Annual Brian P. O’Dell Memorial Research Award, Leukemia and Lymphoma Society (2009); Elected Member, Association of American Physicians (2003).
MD, Harvard Medical School and Harvard-MIT Division of Health Sciences and Technology, Boston, MA (1983); AB, Harvard University, Cambridge, Massachusetts (1978).