Professor and Gilula Chair
The Scripps Research Institute
La Jolla, California
For major technical advances in activity-based protein profiling. His methods exploit the power of chemistry to generate new tools and assays for the global analysis of protein activities, and he has applied these tools to identify new targets and drug candidates for cancer treatment.
The AACR Award for Outstanding Achievement in Chemistry in Cancer Research was established by the AACR and its Chemistry in Cancer Research Working Group in 2007, through the initial support of GlaxoSmithKline, to recognize the importance of chemistry to advancements in cancer research. The award is intended to recognize outstanding, novel, and significant chemistry research that has led to important contributions in basic cancer research, translational cancer research, cancer diagnosis, the prevention of cancer, or the treatment of patients with cancer.
Throughout his career, Cravatt has made numerous important breakthroughs spanning the fields of biochemistry, pharmacology, neuroscience, and chemical biology. He is a pioneer in the field of proteomics and is globally recognized for the development of activity-based methods to profile enzymes on a global scale. He has applied creative proteomic and metabolomic techniques to discover and characterize the function of key enzymes that regulate important lipid-signaling pathways in cancer. Such enzymes have since demonstrated the potential to serve as therapeutic targets. Subsequently, Cravatt has used cutting-edge profiling methods to develop novel selective inhibitors to validate these enzyme targets for the diagnosis and treatment of cancer. To read more, please visit the press release.