Frederick W. Alt, PhD
AACR Award for Lifetime Achievement in Cancer Research

Frederick W. Alt, PhD

Howard Hughes Medical Institute Investigator and Director, Program in Cellular and Molecular Medicine, Boston Children’s Hospital
Charles A. Janeway Professor of Pediatrics
Professor of Genetics, Harvard Medical School
Boston, Massachusetts

For the discovery of gene amplification in mammalian cancer cells, discoveries that contributed to establishing oncogene amplification as a tumor progression mechanism, elucidating non-homologous end-joining, and revolutionizing the understanding of how genomic rearrangements form and how they contribute to cancer.

The AACR Award for Lifetime Achievement in Cancer Research was established in 2004 to honor individuals who have made significant fundamental contributions to cancer research, either through a single scientific discovery or a collective body of work. These contributions, whether they have been in research, leadership, or mentorship, must have had a lasting impact on the cancer field and must have demonstrated a lifetime commitment to progress against cancer.

Dr. Alt is being honored for his discovery of gene amplification in mammalian cancer cells. His research established oncogene amplification as a mechanism of tumor progression and elucidated non-homologous DNA end joining, a pathway that repairs double-strand breaks in DNA. His findings have revolutionized scientific understanding of how genomic rearrangements occur and how they contribute to cancer. To learn more, please visit the press release.

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