Vice Provost of Science;
Senator A.M. Aikin Jr. Distinguished Chair;
Department of Experimental Radiation Oncology Division of Radiation Oncology
The University of Texas MD Anderson Cancer Center,
In recognition of pioneering contributions to determining the biochemical mechanisms of cell cycle regulation and for determining how perturbations in cell cycle control mechanisms contribute to cancer onset. Dr. Piwnica-Worms is also recognized for defining the mechanisms of CDK1 activation and inactivation during a normal cell cycle and demonstrating how its activation is prevented by cell cycle checkpoint mechanisms. Further, her elucidation of CHK1, CDC25, 14-3-3 interactions provided the first direct link between cell cycle checkpoints and mitotic control mechanisms, work which has been essential to the understanding of breast carcinogenesis and has led to additional clinical investigations aimed at targeting cell cycle-related protein kinases including ATR, CHK1, and WEE1 in various cancers.
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