The study of aberrant transcriptional regulation and epigenetic/chromatin changes in hematologic malignancies, including acute promyelocytic leukemia, multiple myeloma, childhood ALL and lymphoma; mutant forms of histone methyl transferases and histones themselves as drivers of malignancy; aberrant gene regulation, specifically the role of abnormal function of histone methyl transferases and histone demethylases in diseases such as multiple myeloma; developing small molecule strategies to normalize gene regulation and treat disease.
Director and Marshall E. Rinker Sr. Foundation and David B. and Leighan R. Rinker Professor, The University of Florida Health Cancer Center; Professor, Departments of Medicine and Biochemistry and Molecular Biology, University of Florida College of Medicine; Attending Physician, University of Florida Health/Shands Hospital, Gainesville, Florida; Adjunct Professor of Medicine and Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Professor, Department of Biochemistry and Molecular Genetics (2014-2015); Johanna Dobe Professor of Hematology/Oncology (2007-2015); and Chief, Division of Hematology/Oncology, Department of Medicine (2006-2015), Northwestern University Feinberg School of Medicine, Chicago, Illinois; Associate Director for Clinical Sciences, Robert H. Lurie Comprehensive Cancer Center of Northwestern University (2006-2015), Chicago, Illinois; Associate Dean for Cancer Programs (2004-2005); Chief, Division of Hematology/Oncology, Department of Medicine, and Ezra M. Greenspan Professor in Clinical Cancer Therapeutics (2003-2005); Vice Chairman for Research, Department of Medicine (2002-2003); Irene and Dr. Arthur M. Fishberg Professor of Medicine (2001-2003) and Associate Professor (with tenure) (1998-2001), Derald H. Ruttenberg Cancer Center and Department of Medicine; Associate Professor (1996-1998) and Assistant Professor (1991-1996), Brookdale Center for Developmental and Molecular Biology and Department of Medicine, Mount Sinai School of Medicine, New York, New York; Instructor in Medicine, Harvard Medical School (1988-1991), Boston, Massachusetts.
Postdoctoral Fellow, Eukaryotic Transcription (1986-1991) and Fellow in Medical Oncology (1985-1988), Dana-Farber Cancer Institute, Harvard Medical School; Resident in Internal Medicine, Beth Israel Hospital, Harvard Medical School (1982-1985), Boston, Massachusetts.
Selected AACR Service, Honors, and Awards
Scientific Editor, Cancer Discovery (2020-present); Editorial Board, Blood Cancer Discovery (2019-present); Member, Honorific Nominating Committee (2019-present); Member, AACR Cancer Progress Report Committee (2018-2019); Chair, AACR Conference on Hematologic Malignancies (2017); Session Chair, Annual Meeting (2017); Member, Annual Meeting Education Committee (2016-2017, 2015-2016); Member, Annual Meeting Program Committee (2016-2017, 2011-2012); Chair, Task Force on Hematological Malignancies (2015-present); Member, AACR NextGen Transformative Grants Scientific Review Committee (2015-2017); Member, Publications Committee (2014-2017); Member, Annual Meeting Exhibits Committee (2014-2017); Plenary Speaker, Annual Meeting (2012); Member, Clinical and Translational Cancer Research Steering Committee (2011-2014); Senior Editor, Clinical Cancer Research (2006-2016).
Selected Non-AACR Service, Honors, and Awards
Member, College of Medicine Dean Search Committee, University of Florida College of Medicine (2020); Chair, Department of Medicine Chair Search Committee, University of Florida College of Medicine (2018); Chair (2017-2019) and Vice Chair (2015-2017), Gordon Conference on Cancer Genetics and Epigenetics; Elected Member, American Association for the Advancement of Science (2017); Elected Member, American Clinical and Climatological Association (2017); Cochair, ASH/EHA Translational Research Training in Hematology Joint Oversight Committee (2017); Member, Scientific Advisory Committee, Genetics Branch, Center for Cancer Research, National Cancer Institute (2016); Member, Medical/Scientific Committee, Leukemia and Lymphoma Society (2016-present); Associate Editor, Oncogene (2016-present); Councilor, American Society of Hematology (2015-2017); Recipient, Mentor of the Year, Northwestern University Feinberg School of Medicine (2015); Member, External Advisory Board, ECOG/ACRN Leukemia Laboratory Committee (2013-present); Member, Editorial Board, Cancer Cell (2012-present); Cochair, International Conference on Differentiation Therapy (2006-2009); Elected Member, Association of American Physicians (2005); Elected Member, American Society for Clinical Investigation (2001).
Certificate, Executive Program for Scientists and Engineers, Kellogg School of Management, Northwestern University, Chicago, Illinois (2008); MD, Columbia University College of Physicians and Surgeons, New York, New York (1982); BS, State University of New York at Stony Brook, New York (1978).