Immune modulation; cancer immunotherapy; regulation; understanding of key strategies and mechanisms to modulate T cell function focusing on the application of this knowledge to cancer immunotherapy; animal models and clinical samples to provide insights toward the identification of biomarkers and/or the design of rational combination clinical trials.
Director, Tumor Immunotherapy Program and Senior Scientist, Ontario Cancer Institute, Princess Margaret Cancer Centre; Professor, Departments of Immunology and Medicine, University of Toronto, Toronto, Ontario, Canada; Canada Research Chair, Tumor Immunity and Immunotherapy, Government of Canada, Ottawa, Ontario, Canada.
Codirector, Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre (2007-2019); Associate Professor (1996-2001) and Assistant Professor (1992-1996), Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Postdoctoral Fellow, University of Zurich (1988-1991), Zurich, Switzerland.
Selected AACR Service, Honors, and Awards
Member, Nominating Committee, Cancer Immunology Working Group (2020); Member, Annual Meeting Clinical Trials Committee (2019-2021); Past Chair (2016-2017), Chair (2015-2016), Chair-Elect (2014-2015), and Member (2008-2013), Steering Committee, Cancer Immunology Working Group; Member, Annual Meeting Program Committee (2017-2018, 2011-2012, 2006-2007); Co-organizer, AACR Tumor Immunology and Immunotherapy Conference (2016); Member, Annual Meeting Education Committee (2015-2016); Founding Senior Editor (2013-2019) and Editor (2019-2021), Cancer Immunology Research; Member, AACR-Cancer Research Institute Lloyd J. Old Award in Cancer Immunology Committee (2013-2015); Member, AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Award Committee (2013-2014).
Selected Non-AACR Service, Honors, and Awards
Invited Speaker, Swiss Immunology Meeting, Bern, Switzerland (2020); Invited Speaker, Tenth Canadian Conference on Ovarian Cancer Research (2020); Member, Executive Council (2019-2021) and Board of Directors (2015-2018), Society for the Immunotherapy of Cancer; Keynote and Plenary Speaker and Session Chair, Australasian Society for Immunology Annual Scientific Conference, Adelaide, Australia (2019); Member, Steering Committee (2018-present) and Site Leader (2011-present), Cancer Immunotherapy Trials Network, National Cancer Institute; Member, Canadian Cancer Society Advisory Council on Research (2018-2021); Member, Steering Committee, Centre for Cell and Vector Production (2018-present); Recipient, University of Manitoba, Distinguished Immunologist Award (2017); Program Lead, Terry Fox Pan Canadian Immunotherapy Network (2016-2021); Member, World Immunotherapy Council (2011-present); Recipient, Canadian Cancer Society’s Robert L. Noble Prize (2018); Recipient, Canadian Society for Immunology Cinader Award: Exceptional Canadian Immunologist (2014); Founding Member, Canadian Cancer Immunotherapy Consortium (2008-present); Executive Editor, European Journal of Immunology (2008-2012); Elected Member, Royal Society of Canada (2006).
PhD, Immunology, University of Toronto (1988); BSc, York University, Toronto, Ontario, Canada (1982).