Professor and Director, Gene Expression Laboratory
March of Dimes Chair in Molecular and Developmental Biology
Salk Institute for Biological Studies
La Jolla, California
For elucidating the complete structure of the human glucocorticoid receptor, which led to the discovery of a nuclear receptor superfamily for steroids, Vitamins A and D, thyroid hormone, bile acids, fatty acids, and cholesterol metabolites. An authority on hormones, he has identified a myriad of primary nuclear receptors as targets for the treatment of many cancers including leukemia, lymphoma, breast cancer, prostate cancer, and pancreas cancer. Additionally, he has discovered a new class of PPAR delta drugs called exercise mimetics, which pharmacologically promote the benefits of fitness and thus has a broad impact in metabolic disease.
The AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research was established by the AACR and Eli Lilly and Co. in 1961 to honor Dr. G.H.A. Clowes, who was a founding member of the AACR and a research director at Eli Lilly. The award is intended to recognize an individual who has made outstanding recent accomplishments in basic cancer research. To learn more, please visit the press release.