Director, Campbell Family Institute for Breast Cancer Research
University Health Network Princess Margaret Cancer Centre
Toronto, Ontario, Canada
For fundamental contributions to the fields of immunology, cancer biology, and cancer therapy, including cloning the beta chain of the human T cell receptor and creating genetically modified mouse strains to elucidate the role of the immune system in tumorigenesis. He also characterized two novel kinases, PLK4 and TTK, now promising targets in Phase II clinical trials, and CTLA-4, a negative regulator of T cell activation, later applied to the development of immune checkpoint blockade therapy.
The Pezcoller Foundation-AACR International Award for Extraordinary Achievement in Cancer Research was established in 1997 to annually recognize a scientist who has made a major scientific discovery in basic or translational cancer research. The awardee must be active in cancer research, have a record of recent noteworthy publications, and be conducting ongoing work that holds promise for continued substantive contributions to progress in the field of cancer.
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View Past Recipients.
View Dr. Mak’s Fellow of the AACR Academy page.