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AACR Special Conference in Cancer Research: DNA Damage Repair: From Basic Science to Future Clinical Application

In association with the AACR Radiation Science and Medicine (RSM) Working Group

January 9-11, 2024
The Mayflower Hotel
Washington, DC

Advance Registration Deadline Tuesday, November 28, 2023

Conference Cochairs

Robert G. Bristow, University of Manchester, Manchester, England
David K. Cortez, Vanderbilt University School of Medicine, Nashville, Tennessee
Susan P. Lees-Miller, University of Calgary, Calgary, AB, Canada
Simon N. Powell, Memorial Sloan Kettering Cancer Center, New York, New York

Radiation Science and Medicine Working Group

The preservation of genomic stability relies heavily on DNA repair pathways and the signaling networks that respond to DNA damage. Errors in DNA repair can have significant consequences for the evolution of tumors and their responses to treatment. Exploiting deficiencies in tumor DNA repair has been a key strategy in oncology for over a century, as demonstrated by the widespread use of treatments like DNA-damaging chemotherapy and ionizing radiation. Substantial progress has been achieved in the field of cancer medicine by effectively targeting DNA repair. A multitude of potent inhibitors focusing on DNA damage response (DDR) have emerged, showing selectivity and promise in clinical settings. However, further investigation is required to understand the challenges relating to mechanisms of resistance, and ongoing preclinical and clinical efforts to develop combinatorial strategies to optimize therapeutic targeting of the DNA damage response and repair pathways. 

This conference aims to exchange and explore the latest advancements in research related to genome maintenance mechanisms and their roles in human health. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. Furthermore, a selection of presentations will be chosen from submitted abstracts, and dynamic poster sessions will encourage the sharing and discussion of ongoing research. Scientists with a vested interest in all facets of DNA metabolism and genome maintenance, spanning from fundamental mechanisms to clinical applications, are strongly encouraged to participate in this conference.