In This Section

Program

Monday, March 2

Tuesday, March 3

Wednesday, March 4

Thursday, March 5

Monday, March 2

Welcome and Keynote Lectures
Introductions by Cory Abate-Shen, Columbia University Irving Comprehensive Cancer Center, New York, New York
5-7 p.m.

Modeling and understanding tumor biologic mechanisms
Ronald A. DePinho, The University of Texas MD Anderson Cancer Center, Houston, Texas

Organoid modeling of tumor and tissue microenvironments
Calvin J. Kuo, Stanford University, Stanford, California

Opening Reception
7-9 p.m.

Tuesday, March 3

Continental Breakfast
7-8 a.m.
Plenary Session 1: Lineage Plasticity, Stem Cells, and Developmental Pathways
Session Chairs: Karuna Ganesh, Memorial Sloan Kettering Cancer Institute, New York, NEW YORK, and Elena Piskounova, Weill Cornell Medicine, New York, NEW YORK
8-10 a.m.

Neuroendocrine differentiation in prostate development and cancer
Michael M. Shen, Columbia University, New York, New York

Developmental reprogramming via Hedgehog pathway activation in nonmyogenic endothelial progenitors drives fusion-negative rhabdomyosarcoma*
Mark Hatley, St. Jude Children’s Research Hospital, Memphis, Tennessee 

Stem cells: Coping with stress and cancer
Elaine Fuchs, Rockefeller University, New York, New York

Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk*
Peter Winter, Massachusetts Institute of Technology, Cambridge, Massachusetts

Signaling networks in small-cell lung cancer
Julien Sage, Stanford University, Stanford, California

Break
10-10:30 a.m.
Plenary Session 2: Modeling the Immune Response and the Tumor Microenvironment
Session Chairs: Alison Taylor, Columbia University Medical Center, New York, NEW YORK, and Camila Dos Santos, Cold Spring Harbor Laboratory, Cold Spring Harbor, NEW YORK
10:30 a.m.-12:30 p.m.

The tissue-specific microenvironment in primary tumors and metastases
Zena Werb, University of California San Francisco, San Francisco, California

Use of CRISPR knock-out screen to identify genes that regulate tumor cell sensitivity to NK cell-based immunotherapy*
Davide Bernareggi, University of California San Diego, San Diego, California

Targeting the pancreas cancer microenvironment to therapeutic advantage
Sunil R. Hingorani, Fred Hutchinson Cancer Research Center, Seattle, Washington

Lymph node colonization promotes distant tumor metastasis through the induction of tumor-specific immunosuppression*
Nathan Reticker-Flynn, Stanford University, Stanford, California

Dynamic single-cell imaging of human cancer growth and therapy responses following engraftment into immunodeficient zebrafish
David Langenau, Massachusetts General Hospital Research Institute, Charlestown, Massachusetts

Lunch on Own
12:30-2:30 p.m.
Plenary Session 3: Modeling Drug Sensitivity and Adaptive Response
Session Chairs: Hariharan Easwaran, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, and Jesse Boehm, Broad Institute, Cambridge, Massachusetts
2:30-4:30 p.m.

Tumor organoid cultures as a platform for functional genomics
Mathew Garnett, Wellcome Sanger Institute, Cambridge, England

A metabolomics discovery profiling approach identifies an E2F1-associated purine synthesis pathway as a major component of the MET-DNA damage response network*
Michaela Medová, Bern University Hospital, Bern, Switzerland

Modeling sensitivity and resistance to systemic therapies in lung cancer
Katerina A. Politi, Yale University, New Haven, Connecticut

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants*
Maria Paz Zafra, Weill Cornell Medicine, New York, New York

The use of GEM tumor models to identify effective therapies against KRAS mutant tumors
Mariano Barbacid, CNIO, Madrid, Spain

Poster Highlights A
Introductions by Cory Abate-Shen, Columbia University Irving Comprehensive Cancer Center, New York, New York
4:30-4:40 p.m.

Modeling the tissue-specific oncogenesis of mutant RAS
Amanda Moore, Genentech, Inc., South San Francisco, California

Coordinate translational control of KRAS signaling pathway in pancreatic adenocarcinoma
Kamini Singh, Memorial Sloan Kettering Cancer Center, New York, New York

A new somatic engineering-based model of small-cell lung cancer development
Kwon-Sik Park, University of Virginia, Charlottesville, Virginia

Strategies to improve engineering cancer-associated SNVs with base editing
Alyna Katti, Weill Cornell Medicine, New York, New York

Poster Session A / Reception
4:40-7 p.m.

Wednesday, March 4

Continental Breakfast
7-8 a.m.
Plenary Session 4: Modeling Tumor Evolution
Session Chairs: Katerina A. Politi, Yale University, New Haven, Connecticut, and Kwon-Sik Park, University of Virginia, Charlottesville, Virginia
8-10 a.m.

From mouse to man: Dissecting cancer mechanisms using mouse models
Cory Abate-Shen, Columbia University, New York, New York

Identification, validation and therapeutic targeting of a driver gene in poor-prognosis breast cancer
Yibin Kang, Princeton University, Princeton, New Jersey

Leveraging single-cell epigenomics to uncover regulatory programs in lung adenocarcinoma*
Lindsey LaFave, Massachusetts Institute of Technology, Cambridge, Massachusetts

Deconstructing the origins of PDAC development
Laura D. Attardi, Stanford University, Stanford, California

Break
10-10:30 a.m.
Model Fidelity Forum
Moderator: Pier Paolo Pandolfi, Dana-Farber Cancer Center, Boston, Massachusetts
10:30 a.m.-12:00 p.m.

Embracing complexity: Changing how we use the mouse to model human cancer
Carol J. Bult, The Jackson Laboratory, Bar Harbor, Maine

The International Human Cancer Models Initiative is generating models annotated with clinical and molecular data
Daniela S. Gerhard, National Cancer Institute, Bethesda, Maryland

A systematic approach to create patient-derived models of rare tumors*
Jesse Boehm, Broad Institute, Cambridge, Massachusetts

Second Keynote Lecture
Introduction by Andrea Califano, Columbia University Medical Center, New York, New York
12-1 p.m.

Defining cancer dependency maps
William C. Hahn, Dana-Farber Cancer Institute, Boston, Massachusetts

Poster Highlights B
Introductions by Cory Abate-Shen, Columbia University Irving Comprehensive Cancer Center, New York, New York
1-1:10 p.m.  

The zebrafish as a mechanical filter: Using zebrafish xenografts to model Ewing sarcoma metastasis in vivo
Dagan Segal, The University of Texas Southwestern Medical Center, Dallas, Texas

Impact of genetic diversity on the growth of human-derived xenografts
Muneer Hasham, The Jackson Laboratory, Bar Harbor, Maine

A hierarchical model of DNA repair inferred from omics-scale genetic interaction data reveals the dynamics of DNA damage induction
Anton Kratz, University of California San Diego, San Diego, California

Predictive modeling, applied to genetically engineered mouse models of breast or lung cancer, provides insights into major oncogenic pathways
Bodo Lange, Alacris Theranostics GmbH, Berlin, Germany

Mechanism-based computational models to study interplay between EGFR inhibitors and KRAS mutants
Edward Stites, Salk Institute for Biological Studies, La Jolla, California

Poster Session B / Lunch
1:10-3:30 p.m.
Plenary Session 5: From Models to the Clinic
Session Chairs: Jinsong Liu, The University of Texas MD Anderson Cancer Center, Houston, Texas, and Michael Shen, Columbia University Medical Center, New York, New York
3:30-5:30 p.m.

Genetic dissection of breast cancer development and therapy resistance in mouse models
Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands

A versatile ES cell-based melanoma mouse modeling platform*
Florian Karreth, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida

MADR: Rapid generation of somatic mosaics with locus-specific, stably integrated transgenic elements for generation of “personalized” mouse models and human organoid tumor models*
Joshua Breunig, Cedars-Sinai Medical Center, Los Angeles, California

Role of autophagy in cancer metabolism
Eileen P. White, Rutgers University, New Brunswick, New Jersey

Modeling cancer in the mouse and its therapeutic implications
Pier Paolo Pandolfi, Dana-Farber Cancer Institute, Boston, Massachusetts

Dinner on Own
5:30 p.m.

Thursday, March 5

Continental Breakfast
7-8 a.m.
Plenary Session 6: Systems Approaches to Interrogating Data from Models
Session Chairs: Andrew White, Cornell University, Ithaca, New York, and Andrea Ventura, Sloan Kettering Institute, New York, New York
8-10 a.m.

Elucidating and targeting mechanisms of single-cell state maintenance: From N-of-1 to N-of-1-of-1 studies
Andrea Califano, Columbia University, New York, New York

Polymerase-mediated ultramutagenesis: A new approach for modeling the high mutational load of human cancer*
Diego Castrillon, UT Southwestern Medical Center, Dallas, Texas

Systems approach to rational combination therapy
Gordon B. Mills, Oregon Health and Science University Knight Cancer Institute, Portland, Oregon

A multiscale map of recurrently mutated systems in cancer*
Fan Zheng, University of California San Diego, San Diego, Californa

Single cell-resolution lineage tracing of tumors in a mouse xenograft model reveals rapid and multidirectional metastasis
Jonathan S. Weissman, University of California San Francisco, San Francisco, California

Break
10-10:30 a.m.
Plenary Session 7: Looking to the Future of Cancer Modeling
Session Chair: Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands
10:30 a.m.-12:30 p.m.

Interrogating therapy response and resistance in engineered preclinical models
Lukas E. Dow, Weill Cornell Medicine, New York, New York

Modeling cancer in the CRISPR era
Andrea Ventura, Memorial Sloan Kettering Cancer Center, New York, New York

Multiplexed functional cancer genomics
Monte M. Winslow, Stanford University, Stanford, California

Developing immunogenic mouse models of cancer
Tyler Jacks, The Koch Institute of MIT, Cambridge, Massachusetts

Closing Remarks
12:30 p.m.

Jos Jonkers, Netherlands Cancer Institute, Amsterdam, Netherlands

*Short talk from proffered abstract