Program
Thursday, October 15, 2020
- Opening Session
- Plenary Session 1: Cancer Immunometabolism
- Plenary Session 2: Epigenetics and Tumor Metabolism 1
- Plenary Session 3: Epigenetics and Tumor Metabolism 2
- Plenary Session 4: Differentiation and Metabolism
Friday, October 16, 2020
- Plenary Session 5: Cancer and Epigenetics
- Plenary Session 6: Emerging Concepts
- Plenary Session 7: Stem Cell Maintenance
- Plenary Session 8: In vivo Cancer Metabolism
Thursday, October 15, 2020
Opening Session
9:30-10:15 a.m.
Opening Remarks/Introduction of Keynote
Kimberly Stegmaier, Dana-Farber Cancer Institute, Boston, Massachusetts
Keynote Address
Metabolic regulation of tumor differentiation
Stephen B. Baylin, Johns Hopkins University School of Medicine, Baltimore, Maryland
Break
10:15-10:30 a.m.
Plenary Session 1: Cancer Immunometabolism
Session Chair: Navdeep S. Chandel, Northwestern University, Chicago, Illinois
10:30 a.m.-12:15 p.m.
Modulating amino-acid metabolism for cancer immunotherapy
Ayelet Erez, Weizmann Institute of Science, Rehovot, Israel
Targeting metabolism to enhance immunotherapy
Jonathan D. Powell, Johns Hopkins School of Medicine, Baltimore, Maryland
Mitochondria as signaling organelles
Navdeep S. Chandel
Mitochondrial lactate metabolism in M2 macrophage polarization and ACLY-dependent histone acetylation*
Jordan Noe, University of Louisville, Louisville, Kentucky
Break
12:15-12:30 p.m.
Plenary Session 2: Epigenetics and Tumor Metabolism 1
Session Chair: Kimberly Stegmaier, Dana-Farber Cancer Institute, Boston, Massachusetts
12:30-2:15 p.m.
Viral mimikry in stem cells and cancer
Andreas Trumpp, German Cancer Research Center (DKFZ), Heidelberg, Germany
Decoding the regulation and function of transcriptional master regulators in cancer metabolism
Johannes Zuber, Research Institute of Molecular Pathology, Vienna, Austria
Dissecting the role of STAG2 mutations in Ewing Sarcoma
Kimberly Stegmaier
Integrated metabolic and epigenomic reprogramming by H3K27M mutations in diffuse intrinsic pontine gliomas*
Sriram Venneti, University of Michigan Medical School, Ann Arbor, Michigan
Break
2:15-2:30 p.m.
Plenary Session 3: Epigenetics and Tumor Metabolism 2
Session Chair: Kathryn E. Wellen, University of Pennsylvania, Philadelphia, Pennsylvania
2:30-4:15 p.m.
Metabolic compartmentalization in the regulation of chromatin modification
Kathryn E. Wellen
Nuclear metabolic-epigenetic axis in learning and memory
Shelley L. Berger, University of Pennsylvania, Philadelphia, Pennsylvania
Deconvoluting variation: Epigenetic roots of disease heterogeneity
J. Andrew Pospisilik, Van Andel Institute, Grand Rapids, Michigan
Metabolic control of polycomb repressive complex 2 in lung disease and lung cancer*
Christine Brainson, University of Kentucky, Lexington, Kentucky
Break
4:15-4:30 p.m.
Plenary Session 4: Differentiation and Metabolism
Session Chair: Olivier Pourquié, Harvard Medical School/Brigham and Women’s Hospital, Boston, Massachusetts
4:30-6:15 p.m.
Crosstalk between cell signaling and metabolism during vertebrate development
Olivier Pourquié
Dynamic metabolic regulation of epigenetic remodeling in macrophages
Jing Fan, University of Wisconsin-Madison, Madison, Wisconsin
Transcriptional regulation of mitochondrial metabolism by TIF1γ drives erythroid progenitor differentiation*
Marlies Rossmann, Harvard University, Cambridge, Massachusetts
Alterations in carbon and nitrogen metabolism in lung cancer*
Jiyeon Kim, University of Illinois at Chicago, Chicago, Illinois
Developing metabolic intervention strategies to reprogram neuroblastoma epigenome and overcome tumor resistance to differentiation therapy
Jiangbin Ye, Stanford University, Stanford, California
Friday, October 16, 2020
Plenary Session 5: Cancer and Epigenetics
Session Chair: Lydia W.S. Finley, Memorial Sloan Kettering Cancer Center, New York, New York
9:30-11:15 a.m.
Impact of metabolic intervention on chromatin remodeling
Alexandre Puissant, Institut Universitaire d’Hématologie (IUH) Saint-Louis, Paris, France
Increasing viral mimicry with vitamin C
Peter A. Jones, Van Andel Institute, Grand Rapids, Michigan
Metabolic regulation of cancer cell fate decisions
Lydia W.S. Finley
Loss of PRC2 or KMT2D-COMPASS generates two quasi-mesenchymal cell states with distinct metastatic abilities*
Yun Zhang, Whitehead Institute for Biomedical Research at MIT, Cambridge, Massachusetts
Break
11:15-11:30 a.m.
Plenary Session 6: Emerging Concepts
Session Chair: Matthew G. Vander Heiden, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts
11:30 a.m.-1:15 p.m.
Metabolic zonation in glioblastoma dictates phenotypic diversification of tumor cells
Eli Keshet, Hebrew University of Jerusalem, Jerusalem, Israel
How nutrient metabolism can influence cell state
Matthew G. Vander Heiden
Clock control of HIF activity and tissue regeneration
Clara Bien Peek, Northwestern University, Chicago, Illinois
Spatial sequestration of GSK3α as a cellular response to amino acid starvation*
Laura Hinze, Boston Children’s Hospital, Boston, Massachusetts
Break
1:15-1:30 p.m.
Plenary Session 7: Stem Cell Maintenance
Session Chair: Omer Yilmaz, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts
1:30-2:45 p.m.
Dietary control of stem cells in physiology and disease
Omer Yilmaz
Lymph protects metastasizing melanoma cells from ferroptosis
Sean J. Morrison, UT Southwestern, Dallas, Texas
Connecting glutamine and citrate metabolism with epigenetic regulation of hematopoiesis*
Dalton Greenwood, Vanderbilt University, Nashville, Tennessee
Break
2:45-3 p.m.
Session 8: In vivo Cancer Metabolism
Session Chair: Ralph J. DeBerardinis, UT Southwestern, Dallas, Texas
3-5:15 p.m.
Metabolic phenotypes and liabilities in human cancer
Ralph J. DeBerardinis
Tracking metabolic compartmentation and epigenetic metabolism in human lung cancer
Teresa W. M. Fan, University of Kentucky, Lexington, Kentucky
Glycolytic compartmentalization within tissues and tumors
Joshua D. Rabinowitz, Princeton University, Princeton, New Jersey
Imaging cancer metabolism in patients: Beyond FDG PET
David A. Mankoff, University of Pennsylvania, Philadelphia, Pennsylvania
IL4 signaling increases acetyl-CoA metabolism and histone acetylation to promote breast cancer metastasis*
Demond Williams, Vanderbilt University, Nashville, Tennessee
Closing Remarks
5:15-5:20 p.m.
Matthew G. Vander Heiden, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts