In This Section

Program

Please Note: All session times for the AACR Virtual Special Conference: Radiation Science and Medicine are U.S. Eastern Standard Time (EST).

Tuesday, March 2, 2021

Wednesday, March 3, 2021

Tuesday, March 2, 2021

Welcome and Opening Keynote Lecture
10-10:40 a.m.

Keynote Lecture
Genomic architecture and targets in hypoxic tumors
Robert G. Bristow, University of Manchester, Manchester, United Kingdom

Break
10:40-10:55 a.m.
Plenary Session 1: Microenvironment
Session Chair: Conchita Vens, the Netherlands Cancer Institute, Amsterdam, Netherlands
10:55 a.m.-12:25 p.m.

Microenvironmental regulation of glioblastoma radioresistance
Philip J. Tofilon, National Cancer Institute, Bethesda, Maryland

Oxygen dependent resistance to PARP inhibitors
Amato Giaccia, University of Oxford, Oxford, United Kingdom

Angiotensin II receptor blockers modify the solid tumor microenvironment and improve radiation therapy response*
Kevin L. Bennewith, BC Cancer, Vancouver, BC, Canada

The impact of gut microbiota on radiotherapy-induced antitumor immune response
Andrea Facciabene, University of Pennsylvania, Philadelphia, Pennsylvania

Break
12:25-12:40 p.m.
Plenary Session 2: Exploiting the DNA Damage Response I
Session Chair: Amato Giaccia, University of Oxford, Oxford, United Kingdom
12:40-2:10 p.m.

Base excision repair and cancer
Joann B. Sweasy, University of Arizona Cancer Center, Tucson, Arizona

Enhancing the therapeutic ratio for glioblastoma by combining radiation therapy with PARP inhibitors
Anthony J. Chalmers, University of Glasgow, Glasgow, United Kingdom

SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation*
David S. Yu, Emory University School of Medicine, Atlanta, Georgia

Exploiting DNA repair defects in head and neck squamous cell carcinoma
Conchita Vens, The Netherlands Cancer Institute, Amsterdam, Netherlands

Break
2:10-2:25 p.m.
Plenary Session 3: Exploiting the DNA Damage Response II
Session Chair: Charles G. Drake, Janssen Research and Development, Spring House, Pennsylvania
2:25-4:20 p.m.

Etiology of chromosomal rearrangements, and other DNA double-strand break repair outcomes
Jeremy Stark, City of Hope, Duarte, California

TGFβ regulation of DNA repair across cancer types predicts response to genotoxic therapies
Mary Helen Barcellos-Hoff, University of California San Francisco, San Francisco, California

Radiosensitization by targeting the NPM1/RAD51 axis*
Michael L. Freeman, Vanderbilt University School of Medicine, Nashville, Tennessee

Deciphering DNA end resection at DSBs
Dipanjan Chowdhury, Dana-Farber Cancer Institute, Boston, Massachusetts

Translation to clinical trials: Are we shooting the right arrows at the target?
Ricky Sharma, Varian Medical Systems, Palo Alto, California
not eligible for CME credit

Break
4:20-4:35 p.m.
Plenary Session 4: Immunotherapy
Session Chair: Ralph Weichselbaum, University of Chicago, Chicago, Illinois
4:35-6:05 p.m.

Differential immunological effects of carbon-ion versus photon radiation therapy
Charles G. Drake, Janssen Research and Development, Spring House, Pennsylvania

Integrating radiation therapy with immunotherapy
Marka R. Crittenden, Earle A. Chiles Research Institute, Portland, Oregon

Radiation modulates hepatic siphoning of T cells to improve immunotherapy efficacy*
Michael Green, University of Michigan, Ann Arbor, Michigan

Strategies to enhance the immunogenicity of radiation therapy
Silvia C. Formenti, Weill Cornell Medical College, New York, New York

Wednesday, March 3, 2021

Plenary Session 5: Hypoxia
Session Chair: Robert G. Bristow, University of Manchester, Manchester, United Kingdom
10-11:55 a.m.

Hypoxia-induced SETX links replication stress with the unfolded protein response
Ester M. Hammond, University of Oxford, Oxford, United Kingdom

Metabolic deregulation drives a redox vulnerability in pancreatic cancer
Marianne Koritzinsky, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Adenosine signaling and radiation-induced immunosuppressive changes to the tumor microenvironment*
Catherine S. Spina, Columbia University Irving Medical Center, New York, New York

Chromatin and gene transcription in hypoxia
Sonia Rocha, University of Liverpool, Liverpool, United Kingdom

Molecular landmarks of tumor hypoxia across cancer types
Paul Boutros, University of California Los Angeles, Los Angeles, California

Break
11:55 a.m.-12:10 p.m.
Plenary Session 6: Limiting Late Effects: Physics, Biology, and Genetics
Session Chair: David R. Gius, Mays Cancer Center UT Health San Antonio, San Antonio, Texas
12:10-1:40 p.m.

Preclinical studies with proton FLASH radiotherapy in mice and canines: Biological effects, biophysical considerations, and potential mechanisms
Constantinos Koumenis, University of Pennsylvania, Philadelphia, Pennsylvania

Optimizing stem cell nice for post-irradiation regeneration
Rob Coppes, University Medical Center Groningen, Groningen, Netherlands

Pulsed low-dose-rate radiation (PLDR) limits pancreatic pro-tumor stroma aggravation: Pre-clinical basis for an ongoing PLDR trail*
Janusz Franco-Barraza, Fox Chase Cancer Center, Philadelphia, Pennsylvania

Predicting radiotherapy outcomes: Radiogenomics and risk of radiotherapy toxicity
Catharine M.L. West, University of Manchester, Manchester, United Kingdom

Break
1:40-1:55 p.m.
Plenary Session 7: Sirtuins, Cell Homeostasis, and Metabolism
Session Chair: Ester M. Hammond, University of Oxford, Oxford, United Kingdom
1:55-3:50 p.m.

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
David Gius, Mays Cancer Center UT Health San Antonio, San Antonio, Texas

The role of sirtuins in radiation-induced cardiac dysfunction
Carmen R. Bergom, Washington University in St. Louis, St. Louis, Missouri

Targeting FASN improves type I interferon responses in irradiated glioblastoma*
Mara De Martino, Weill Cornell Medicine, New York, New York

Sirt2: A tumor suppressor or promotor?
Fen Xia, University of Arkansas for Medical Sciences, Little Rock, Arkansas

Exploiting redox biology for selectively targeting cancer cells
Douglas R. Spitz, University of Iowa, Iowa City, Iowa

Break
3:50-4:05 p.m.
Plenary Session 8: Molecular Predictions
Session Chair: Mary Helen Barcellos-Hoff, University of California, San Francisco, San Francisco, California
4:05-5:35 p.m.

Gaps alone kill BRCA deficient cancer cells
Sharon Cantor, University of Massachusetts Medical School, Worcester, Massachusetts

Dysregulated metabolic and immune pathways underlying radiation fibrosis and lymphedema
Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Identification and characterization of the molecular mechanisms of SCLC chemo-radiation resistance*
Francesca Anna Carrieri, Johns Hopkins University, Baltimore, Maryland

Interaction of radiotherapy and immunotherapy: Maybe not what you think
Ralph Weichselbaum, University of Chicago Medicine, Chicago, Illinois

Closing Remarks
5:35-5:40 p.m.

David R. Gius, Mays Cancer Center UT Health San Antonio, San Antonio, Texas

*Short talk from proffered abstract