In This Section

Program

Please Note: All session times for the AACR Virtual Special Conference: Artificial Intelligence, Diagnosis, and Imaging are U.S. Eastern Standard Time (EST).

Tuesday, March 2, 2021

Wednesday, March 3, 2021

Tuesday, March 2, 2021

Welcome and Opening Keynote Lecture
10-10:40 a.m.

Keynote Lecture
Genomic architecture and targets in hypoxic tumors
Robert G. Bristow, University of Manchester, Manchester, United Kingdom

Break
10:40-10:55 a.m.
Plenary Session 1: Microenvironment
Session Chair: Conchita Vens, Netherlands Cancer Institute, Amsterdam, Netherlands
10:55 a.m.-12:25 p.m.

Influence of the microenvironment on brain tumor radiosensitivity
Philip J. Tofilon, National Cancer Institute, Bethesda, Maryland

Title to be announced
Amato Giaccia, University of Oxford, Oxford, United Kingdom

The impact of gut microbiota on radiotherapy-induced antitumor immune response
Andrea Facciabene, University of Pennsylvania, Philadelphia, Pennsylvania

Short talk from proffered abstract

Break
12:25-12:40 p.m.
Plenary Session 2: Exploiting the DNA Damage Response I
Session Chair: Amato Giaccia, University of Oxford, Oxford, United Kingdom
12:40-1:40 p.m.

Base excision repair and cancer
Joann B. Sweasy, University of Arizona Cancer Center, Tucson, Arizona

Combining radiation therapy with inhibitors of the DNA damage response
Anthony J. Chalmers, University of Glasgow, Glasgow, United Kingdom

Title to be announced
Conchita Vens, Netherlands Cancer Institute, Amsterdam, Netherlands

Short talk from proffered abstract

Plenary Session 3: Exploiting the DNA Damage Response II
Session Chair: Charles G. Drake, Janssen R&D, Spring House, Pennsylvania
2:20-4:15 p.m.

Etiology of chromosomal rearrangements, and other DNA double-strand break repair outcomes
Jeremy Stark, City of Hope, Duarte, California

Title to be announced
Mary Helen Barcellos-Hoff, University of California San Francisco, San Francisco, California

Title to be announced
Dipanjan Chowdhury, Dana-Farber Cancer Institute, Boston, Massachusetts

Translation to clinical trials: Are we shooting the right arrows at the target?
Ricky Sharma, Varian, Palo Alto, California

Short talk from proffered abstract

Plenary Session 4: Immunotherapy
Session Chair: Ralph Weichselbaum, University of Chicago, Chicago, Illinois
4:30-6 p.m.

Title to be announced
Charles G. Drake, Janssen R&D, Spring House, Pennsylvania

Integrating radiation therapy with immunotherapy
Marka R. Crittenden, Earle A. Chiles Research Institute, Portland, Oregon

Title to be announced
Silvia C. Formenti, Weill Cornell Medical College, New York, New York

Short talk from proffered abstract

Wednesday, March 3, 2021

Plenary Session 5: Hypoxia
Session Chair: Robert G. Bristow, University of Manchester, Manchester, United Kingdom
10-11:55 a.m.

Title to be announced
Ester M. Hammond, University of Oxford, Oxford, United Kingdom

Metabolic deregulation drives a redox vulnerability in pancreatic cancer
Marianne Koritzinsky, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Hypoxia impacts on chromatin structure
Sonia Rocha, University of Liverpool, Liverpool, United Kingdom

Hypoxia shapes tumor evolutionary landscapes
Paul Boutros, University of California Los Angeles, Los Angeles, California

Short talk from proffered abstract

Break
11:55 a.m.-12:10 p.m.
Plenary Session 6: Limiting Late Effects: Physics, Biology, and Genetics
Session Chair: David R. Gius, Mays Cancer Center UT Health San Antonio, San Antonio, Texas
12:10-1:40 p.m.

Studies with proton FLASH radiotherapy in mouse and canine tumor models
Constantinos Koumenis, University of Pennsylvania, Philadelphia, Pennsylvania

Optimizing stem cell nice for post-irradiation regeneration
Rob Coppes, University Medical Center Groningen, Groningen, Netherlands

Biomarkers to predict radiotherapy outcomes
Catharine West, University of Manchester, Manchester, United Kingdom

Short talk from proffered abstract

Break
1:40-1:55 p.m.
Plenary Session 7: Sirtuins, Cell Homeostasis, and Metabolism
Session Chair: Ester M. Hammond, University of Oxford, Oxford, United Kingdom
1:55-3:50 p.m.

Title to be announced
David Gius, Mays Cancer Center UT Health San Antonio, San Antonio, Texas

The role of sirtuins in radiation-induced cardiac dysfunction
Carmen R. Bergom, Washington University in St. Louis, St. Louis, Missouri

Sirt2: A tumor suppressor or promotor?
Fen Xia, University of Arkansas for Medical Sciences, Little Rock, Arkansas

Exploiting redox biology and metabolism for improving cancer therapy
Douglas R. Spitz, University of Iowa, Iowa City, Iowa

Short talk from proffered abstract

Break
3:50-4:05 p.m.
Plenary Session 8: Molecular Predictions
Session Chair: Mary Helen Barcellos-Hoff, University of California, San Francisco, San Francisco, California
4:05-5:35 p.m.

Focusing on the gap in chemotherapy response
Sharon Cantor, University of Massachusetts Medical School, Worcester, Massachusetts

Dysregulated metabolic and immune pathways underlying radiation fibrosis and lymphedema
Fei-Fei Liu, Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Interaction of radiotherapy and immunotherapy maybe not what you think
Ralph Weichselbaum, University of Chicago, Chicago, Illinois

Short talk from proffered abstract

Closing Remarks
5:35-5:40 p.m.