Program
Please Note: All session times for the AACR Virtual Meeting: Sarcomas are U.S. Eastern Daylight Time (EDT).
Monday, June 28, 2021
Welcome and Keynote Address
11-11:35 a.m.
Keynote Address
Sandra D’Angelo, Memorial Sloan Kettering Cancer Center, New York, New York
Break
11:35-11:45 a.m.
Plenary Session 1: Model Systems
11:45 a.m.-1:10 p.m.
Sarcoma patient-derived tumor organoids to investigate tumor heterogeneity and drug responses
Alice Soragni, University California Los Angeles, Los Angeles, California
Zebrafish modeling of pediatric sarcoma
Genevieve Kendall, Nationwide Children’s Hospital, Columbus, Ohio
Development of a phenotypically diverse model of soft tissue sarcoma to identify key drivers of sarcoma tumorigenesis
Janai Carr-Ascher, University California Davis, Sacramento, California
Title to be announced
Angela Hirbe, Washington University in St. Louis, St. Louis, Missouri
Panel Discussion
Break
1:10-1:30 p.m.
Plenary session 2: Signaling
1:30–2:55 p.m.
Targeting fusion dependent molecular pathways in CIC-rearranged sarcoma
Ross Okimoto, University of California San Francisco, San Francisco, California
Targeting cell cycle dysregulation in GIST
Inga-Marie Schaefer, Brigham and Women’s Hospital, Boston, Massachusetts
Profiling the osteosarcoma microenvironment to identify context – specific therapeutic targets
Troy McEachron, National Institutes of Health, Bethesda, Maryland
An essential requirement for amino acid activation of mTORC1 underlies mTOR inhibitor dependence in PAX3-FOXO1 rhabdomyosarcoma
Amit Sabnis, University California San Francisco, San Francisco, California
Panel Discussion
Closing Remarks for the day
2:55-3 p.m.
Tuesday, June 29, 2021
Keynote Address
11-11:35 a.m.
Keynote Address
Ryan Roberts, Nationwide Children’s Hospital, Columbus, Ohio
Break
11:35-11:45 a.m.
Plenary Session 3: Immunotherapy
11:45 A.M.-1:10 p.m.
Title to be announced
Robbie Majzner, Stanford University, Stanford, California
Developing Th1 vaccines to prevent relapse in liposarcoma
Laura Riolobos, University of Washington, Seattle, Washington
Modulating tumor milieu to enhance sarcoma immunotherapy
Alex Huang, Case Western Reserve University, Cleveland, OHhio
Title to be announced
Emily Keung, The University of Texas MD Anderson Cancer Center, Houston, Texas
Panel Discussion
Break
1:10-1:30 p.m.
Plenary session 4: Gene Regulation
1:30 p.m.–2:55 p.m.
Ewing sarcoma: An enhancer disease with widespread epigenetic heterogeneity
Eleni Tomazou, Children’s Cancer Research Institute, St. Ann Kinderkrebsforschung, Vienna, Austria
Phasing R-loops in and out by FET proteins and their fusions
Jacob Schwartz, University of Arizona, Tucson, Arizona
Epigenetic determinants of tumor heterogeneity in Synovial Sarcoma
Nicolo Riggi, UNIL- Université de Lausanne, Switzerland
When a mutation profoundly alters chromatin dynamics and modulates oncogene regulation
Didier Surdez, Curie Institute, Paris, France
Panel Discussion