AACR-Genentech Immuno-oncology Research Fellowship
The AACR-Genentech Immuno-oncology Research Fellowship represents a joint effort to encourage and support postdoctoral or clinical research fellows to conduct immuno-oncology research and to establish a successful career path in this field. Funded research can be basic, translational, or clinical in nature.
Dr. Wang’s current research focuses on understanding how papillomavirus evades the host immune response to establish persistent infection. She previously showed that stress keratin 17 (K17) is a key regulator in the prevention of T cell infiltration in mouse papillomavirus-induced lesions. In her funded work, she aims to elucidate the molecular mechanisms underlying K17 expression and K17-mediated regulation of T cell infiltration using mouse papillomavirus, MmuPV1, as a model.
Dr. Wang graduated with her PhD from the cellular and molecular pathology program at the University of Wisconsin-Madison. She is currently a postdoctoral trainee at the same university, where she is working on the role of stress keratin 17 in host immune response using mouse papillomavirus as a model.
Acknowledgment of Support
The 2020 AACR-Genentech Immuno-oncology Research Fellowship will support my proposed study of investigating mechanisms of immune response regulation by K17 in cancer and help me transition to an independent researcher with the goal of applying what I learn from this study to improve current immunotherapy efficacy.
Although the molecular basis for the phenotypic, functional specialization, and epigenetic reprogramming of tumor infiltrating exhausted CD8 T-cell has been well addressed, that of exhausted innate cells have not been fully addressed. Dr. Seo is analyzing the transcriptional and epigenetic landscape of tumor-infiltrating immune cells. In addition, he is exploring the role of TET2 in epigenetic reprogramming of innate and adaptive immune cells within tumors.
Dr. Seo received his PhD in immunology from Seoul National University. His postdoctoral research focuses on elucidating the mechanisms underlying immune cell exhaustion by epigenetic reprogramming
Acknowledgement of Support
I am greatly honored to be awarded AACR-Genentech Immuno-oncology Research Fellowship. This award gives me an opportunity to advance our knowledge for epigenetic reprogramming of tumor-infiltrating immune cells. This award will not only provide insights into novel strategies for cancer immunotherapy, but also facilitate my carrier into an independent scientist.