SU2C Meg Vosburg T-Cell Lymphoma Dream Team: Tailoring CAR-based Immunotherapy Strategies to T-cell Lymphoma
Cancer immunotherapy has had a tremendous impact on a wide range of cancers, including B-cell lymphomas. However, it has not yet been effective in those lymphomas that originate primarily from T cells. The scientific challenge is in finding a therapy that can attack the cancerous T cells while leaving normal cells intact.
The SU2C Meg Vosburg T-cell Lymphoma Dream Team is testing engineered cells that carry molecules known as chimeric antigen receptors, or CARs, which can lock onto proteins on the surface of cancerous T cells and destroy them. Finding the best combination of CARs and engineered cell types is a key goal of the Dream Team.
CAR therapy is usually custom-built for each patient. The team is trying to find a way to develop CAR cells on an “off-the-shelf” basis so the therapy will be more available to patients and less expensive.
This team in named in honor of Mary Margaret (Meg) Moretti Vosburg, a lifelong learner, educator and humanitarian, who died May 26, 2018, after a hard-fought battle with lymphoma at the age of 51.
Amount Of Funding
Baylor College of Medicine:
- Malcolm K. Brenner, MD, PhD, investigator
- Carlos Ramos, MD, investigator
- Maksim Mamonkin, PhD, young investigator
- LaQuisa Hill, MD, young investigator
- Rayne Rouce, MD, young investigator
- Natasha Lapteva, PhD, investigator
University of North Carolina-Chapel Hill:
- Barbara Savoldo, MD, PhD, investigator
- Anne Beaven, MD, investigator
- Natalie Grover, MD, young investigator
- Joel Parker, PhD, investigator
- Paul Eldridge, PhD, investigator
The University of Texas MD Anderson Cancer Center:
- Katy Rezvani, MD, PhD, Dream Team principal
- Elizabeth J. Shpall, MD, investigator
- May Daher, MD, young investigator
Wake Forest Baptist Health Comprehensive Cancer Center:
- Bayard Powell, MD, Dream Team principal
- Timothy S. Pardee, MD PhD, investigator
- Wei Zhang, PhD, investigator
- Zanetta S. Lamar, MD, young investigator
- Patty Spears, UNC Lineberger Patient Research Advocacy Group Gustavo Ayala, MD, University of Texas in Houston, parent of a teenager with T-cell lymphoma
- Bambi Grilley, director of Clinical Research and Early Product Development at Cell and Gene Therapy at Baylor College of Medicine
- Ruth Sorelle, retired journalist and survivor of NK-T cell lymphoma