AACR Anna D. Barker Basic Cancer Research Fellowship

The AACR Anna D. Barker Basic Cancer Research Fellowship represents an effort to encourage and support mentored young investigators to conduct basic cancer research and to establish successful career paths in this field. Eligibility is limited to postdoctoral and clinical research fellows who have completed their most recent doctoral degree within the past three years. The research proposed for funding may be in any area of basic cancer research.

2022 Grantee

Hsiwen Yeh, PhD

Hsiwen Yeh, PhD

Postdoctoral Fellow

The Rockefeller University

New York, New York

The role of mitochondrial glutathione in tumor initiation and progression


Cancer cells exhibit dramatic alterations in cellular metabolism to support cell growth, proliferation, and survival. However, the role of metabolism in late-stage tumor progression is less studied. Through organellar proteomics and metabolomics approaches, mitochondrial antioxidants have been identified as major contributors to cancer dissemination. Dr. Yeh aims to elucidate the roles of compartmental antioxidants in disease pathogenesis and tumor progression, and to identify potential therapeutic targets for cancer.


Dr. Yeh received his doctoral degree at National Defense Medical Center in Taiwan, where he studied cancer metastasis and gene regulation. After completing his graduate training, he joined Rockefeller University as a postdoctoral research fellow. His research focuses on the role of oxidative metabolism in tumorigenesis.

Acknowledgement of Support

Receiving the AACR Anna D. Barker Basic Cancer Research Fellowship is a great honor. The fellowship represents an excellent opportunity to achieve my research goals of providing new insights in the field of cancer metabolism and identifying prognostic and therapeutic strategies to prevent cancer metastasis.