TEAM LEADER
Francisca Vazquez, PhD
Director
Cancer Dependency Map
Broad Institute
Cambridge, Massachusetts
TEAM MEMBERS
Jesse S. Boehm, PhD
Catarina Campbell, PhD
Glenn Cowley, PhD
Joshua M. Dempster, PhD
Levi A. Garraway, MD, PhD, FAACR
Todd R. Golub, MD, FAACR
William C. Hahn, MD, PhD
James McFarland, PhD
Philip Montgomery, MS
David E. Root, PhD
Jennifer A. Roth, MBA, MA
William R. Sellers, MD, FAACR
Yuen-Yi “Moony” Tseng, PhD, MS
Aviad Tsherniak, MS
Barbara A. Weir, PhD
For pioneering the systematic mapping of genetic dependencies across cancer cells, creating a comprehensive resource that reveals genes and pathways essential for tumor survival. By combining large-scale CRISPR functional genomic screens, drug response data, and multi omic profiling, the Cancer Dependency Map team has uncovered lineage- and genotype- specific cancer vulnerabilities, including synthetic lethal dependencies such as WRN in microsatellite instability cancers and PRMT5 dependencies in cancers harboring MTAP deletions. Their work has transformed the discovery and prioritization of therapeutic targets and has become a foundational resource for cancer research and drug development worldwide.
The AACR Team Science Award recognizes an outstanding interdisciplinary research team for its innovative and meritorious science that has advanced or likely will advance our fundamental knowledge of cancer, or a team that has applied existing knowledge to advance the detection, diagnosis, prevention, or treatment of cancer. To learn more, please visit the press release.
View Past Recipients.