Celebrated for his contributions to translational and clinical advances in multiple myeloma, Dr. Anderson has transformed medical practice and markedly improved multiple myeloma patient outcomes worldwide. His research has focused on utilizing surrogate models of multiple myeloma to better understand biological mechanisms such as cell survival, death, and growth, immune response, drug resistance, and tumor heterogeneity; how such mechanisms influence cancer onset and progression; and how these processes may be molecularly manipulated by targeted therapeutics.
Dr. Anderson’s research has emphasized the role of the tumor microenvironment in carcinogenesis and has led to the preclinical and clinical development, leading to FDA approval, of the proteasome inhibitor bortezomib and the immunomodulatory drug lenalidomide. These agents in combination as front-line treatments have prolonged the median survival time of patients with multiple myeloma from 3 to over 7 years.
Ongoing research endeavors in Dr. Anderson’s laboratory have been dedicated to identifying novel targets and validating targeted therapies, as well as developing combinatorial drug strategies for multiple myeloma. This research has featured several drugs recently FDA approved for use in subpopulations of multiple myeloma patients, including pomalidomide (immunomodulator) and panobinostat (HDAC inhibitor), as well as novel monoclonal antibodies (elotuzumab and daratumamab), currently in late stages of regulatory approval.
2014 David Workman Memorial Award, Samuel Waxman Cancer Research Foundation
2013 Leonard P. Zakim Patient Advocacy Award
2012 Medal of Honor for Basic Research, American Cancer Society
2012-2015 Board of Directors, AACR
2011 Clinical Research Award, Hope Funds for Cancer Research
2011 David A. Karnofsky Memorial Award and Lecture, American Society of Clinical Oncology
2010 Elected Member, Institute of Medicine
2010 Elected Member, Royal College of Physicians and Pathologists, London
2009 Honorary Doctorate, University of Athens School of Medicine, Athens
2008 Dameshek Prize, American Society of Hematology
2007 AACR-Joseph H. Burchenal Memorial Award for Outstanding Achievement in Clinical Cancer Research
2007-Present Editor-in-Chief, Clinical Cancer Research
2005 Robert A. Kyle Lifetime Achievement Award, International Myeloma Foundation
2003 Waldenström Award for Myeloma Research
1977 MD, Johns Hopkins University School of Medicine