Research Interests
Signal transduction pathways; role of RAS proteins in cancer initiation and progression; development of cell-based and animal-based models in the study of inflammation and immunity in RAS-driven tumorigenesis; characterization of feedback mechanisms that control the functional output of the RAS signaling axis; utilization of chemical biology approaches to identify new modalities for therapeutic targeting; oncogene function in pancreatic cancer.
Current Affiliations
Professor, biochemistry and molecular pharmacology; executive vice president and vice dean for science, medicine; professor, medicine, New York University Grossman School of Medicine, New York, New York.
Previous Positions
Professor, biochemistry and molecular pharmacology, New York University School of Medicine (2006-2019), New York, New York; chair, biochemistry, New York University School of Medicine (2006-2011), New York, New York; chair (2003-2006), professor (1998-2002), and associate professor (1995-1998), molecular genetics and microbiology, State University of New York, Stony Brook, New York; senior staff investigator (1989-1995) and staff investigator (1987-1989), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Education
PhD, cell biology, State University of New York at Stony Brook, New York (1984); MSc (1980) and BSc (1976), biochemistry, Bar-Ilan University, Ramat Gan, Israel.
Postdoctoral Training
Postdoctoral fellow, Cold Spring Harbor Laboratory (1984-1987), Cold Spring Harbor, New York.
Selected AACR Service, Honors, and Awards
Fellow, AACR Academy (2019); cochair, AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care (2019); recipient, AACR Charlotte Friend Memorial Lectureship Award (2018); member, Science Education and Career Advancement Committee (2018-2021); member, Laboratory Research Awards Committee (2018-2020, 2006-2008); member, Board of Directors (2016-2019); member, Publications Committee (2016-2019); member, AACR NextGen Grants for Transformative Cancer Research Committee (2016-2018); chair, Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant Scientific Review Committee (2016-2017); member, Scientific Program Committee (2015); member, Stand Up To Cancer Innovative Research Grants Committee (2015-2016); cochair, AACR Special Conference in Pancreatic Cancer: Innovations in Research and Treatment (2014); cochair, AACR Special Conference in Ras Oncogenes: From Biology to Therapy (2014); member, Cancer Immunology Working Group (2013-present); member, Tumor Microenvironment Working Group (2013-present); member, Tellers Committee (2013-2014); cochair, AACR Special Conference in Pancreatic Cancer: Progress and Challenges (2012); member (2011-2014) and cochair (2020-2024), Special Conferences Committee; chair, Pancreatic Cancer Action Network-AACR Pilot Grants Scientific Review Committee (2009); chair (2009) and member (2006-2008), Research Grants Review Committee; cochair (2008, 2011) and member (2010, 2013), Annual Meeting Program Committee.
Selected Honors, Awards, and Non-AACR Service
Keynote lecturer, European Society for Medical Oncology Conference, Barcelona, Spain (2019); distinguished lecturer in cancer biology, The University of Texas MD Anderson Cancer Center (2019); distinguished lecturer in cancer research, The Wistar Institute (2019); keynote speaker, Cold Spring Harbor Laboratory Meeting “Biology of Cancer: Microenvironment and Metastasis” (2019); chair (2018-2021) and member (2013-present), National Cancer Institute Board of Scientific Advisors; speaker, Translational Research Perspectives in Pancreatic Cancer, American Medical Center Hospital (JCI) Sheba Medical Center, Israel (2018); recipient, Julia Hudson Freund Lecture, Washington University School of Medicine, St. Louis(2015); recipient, Lola and John Grace Distinguished Lectureship in Cancer Research, Swiss Institute for Experimental Cancer Research, Lausanne (2013); chair (2008-2010) and member (2006-present), Scientific Advisory Board, Pancreatic Cancer Action Network; member, Scientific Review Board, Starr Cancer Consortium (2010-2015); member, NIH Review Panel for Director’s New Innovator Awards (2007-2008); member, Board of Scientific Counselors, National Cancer Institute (2006-2011); recipient, National Cancer Institute MERIT Award (1996-2006).