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Progress Against Cancer

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Recent Progress

Hypoxia and the Lethal Cancer Phenotype: A Conversation with Nobel Laureate Gregg Semenza

Hypoxia and the Lethal Cancer Phenotype: A Conversation with Nobel Laureate Gregg Semenza

In the early 1990s, Gregg Semenza, MD, PhD, was a postdoctoral researcher studying the cellular response to reduced oxygen levels, a state known as hypoxia. His focus was on the erythropoietin gene, EPO, which controls red blood cell production, and thus oxygen delivery. After identifying a sequence within the EPO gene that was critical for the response to hypoxia, Semenza isolated a mystery protein that was bound to this sequence.

From the Journals: Editors’ Picks

From the Journals: Editors’ Picks

Every month, the editors from the portfolio of scientific journals published by the AACR select one “must read” article from each issue, which we summarize here. The May edition includes a description of a deep learning-based algorithm to examine the tumor microenvironment in lung cancer for risk prediction, an examination of the role that the protein myocilin plays in cancer-associated cachexia, along with results from two clinical trials, among other studies.