AACR-Swim Across America Cancer Research Fellowship

The AACR-Swim Across America Cancer Research Fellowship represents a joint effort to encourage and support a postdoctoral or clinical research fellow to conduct cancer research and establish a successful career path.

2020 Grantee

Manisha Jalan, DPhil

Manisha Jalan, DPhil

Research Scholar
Memorial Sloan Kettering Cancer Center
New York, New York
Alternate DNA repair pathways in homologous recombination-deficient cancers

Double strand breaks (DSBs) in DNA, if not repaired faithfully, can lead to mutations, chromosomal rearrangements, and even cell death. Due to its error-free nature, homologous recombination (HR) is the preferred pathway to deal with DSBs. HR-deficient tumors utilize alternate repair pathways to keep cells alive. Dr. Jalan aims to develop a high throughput assay to test if DNA breaks can be repaired using an alternative template, other than DNA, to ensure genome stability. She seeks to identify novel and interesting factors that could stimulate novel therapeutic approaches by exploiting synthetic lethality in HR-deficient cancers.

Dr. Jalan completed her PhD at the University of Oxford, where she identified genetic factors required during recombination dependent replication restart in yeast. Currently a research scholar at Memorial Sloan Kettering Cancer Center, she is working on understanding the DNA damage response in mammalian cells.

Acknowledgment of Support
It is my great privilege to receive the 2020 AACR-Swim Across America Cancer Research Fellowship. I would like to thank the review committee and my mentor Dr. Powell for supporting my application. This prestigious award is an important step in my career to build the foundation to be an independent researcher.