The AACR-QuadW Foundation Fellowship for Clinical/Translational Sarcoma Research represents a joint effort to encourage and support a postdoctoral or clinical research fellow to work on mentored sarcoma research and to establish a successful career path in this field. Funded research may be translational or clinical in nature.

2025 Grantee

Scientific Statement of Research  

While multimodal chemotherapy combined with surgical resection has resulted in an approximately 70% disease-free five-year survival rate in patients with localized osteosarcoma (OS), patients with metastatic disease fare far worse. Therefore, new treatment strategies are desperately needed for patients with this aggressive malignancy. To identify potential targeted combinations with PARPi, Dr. Morsby exploited a genome scale loss-of-function CRISPR-Cas9 synergy screen in two OS cell lines in the presence and absence of the FDA-approved PARPi olaparib over a period of 14 days. ATM emerged as a top druggable sensitizer to PARPi in both cell lines. This funded project is designed to test the hypothesis that dual inhibition of ATM and PARP will lead to pediatric OS cell death in vitro and in vivo via apoptosis.

Biography  

Dr. Morsby completed her doctorate at the University of Notre Dame in 2023, where her work focused on utilizing novel near-infrared probes to monitor hypoxic regions of tumors. She is currently a postdoctoral research associate at St. Jude Children’s Research Hospital working on validating the dual inhibition of ATM and PARP as a novel therapy for pediatric osteosarcoma. 

Acknowledgment of Support 

“I am extremely honored and grateful to be awarded the AACR-QuadW Foundation Sarcoma Research Fellowship in Memory of Willie Tichenor. This project has high clinical relevance, as current treatment options being explored for pediatric OS patients are very limited. Receiving this award means I will have the funding necessary to complete and publish this work, which can directly impact patients.”