Neuroendocrine Tumor Research Foundation-AACR Grant

Formerly the Caring for Carcinoid Foundation, the Neuroendocrine Tumor Research Foundation updated its name in 2015 to better reflect the current medical terminology for the disease and to include all those who are affected by neuroendocrine cancer in their community of support. The Neuroendocrine Tumor Research Foundation-AACR Grant represents a joint effort to promote and support innovative cancer research. Funded research can be in any discipline of basic, translational, clinical, or epidemiological cancer research.

2020 Grantee

Etay Ziv, MD, PhD

Etay Ziv, MD, PhD

Assistant Attending Radiologist
Sloan Kettering Institute for Cancer Research
New York, New York
Emergence of high-grade and treatment-resistant pancreatic NET subclones

Well-differentiated pancreatic neuroendocrine tumors (pNETs) represent a heterogeneous group of tumors with variable degree of aggressiveness. Treatment response and overall prognosis is largely determined by tumor grade. It is unknown when and how high-grade tumors arise in the overall course of the disease and in relation to treatment. Using multiregion sampling from primary and metastatic sites over multiple time points, Dr. Ziv’s team is set to reconstruct tumor phylogeny to determine the timing of the emergence of high grade subclones and to identify subclones selected for after therapy.

Dr. Ziv earned a dual MD, PhD degree at Columbia University, where his dissertation focused on developing machine learning tools to understand the structure and function of gene networks. He completed his intern year at Mount Sinai University and his residency and fellowship at the University of California, San Francisco. He is currently an interventional radiologist at Memorial Sloan Kettering Cancer Center and Director of the Laboratory for Interventional Oncology. His research efforts are focused on understanding neuroendocrine tumor evolution and transformation using a combination of computational techniques and cell line models. He is a recipient of the 2019 Gary Becker Young Investigator Award from the Society of Interventional Radiology.

Acknowledgement of Support
We are very grateful for the 2020 Neuroendocrine Tumor Research Foundation-AACR Grant that will enable us to catalog the subclonal evolution of pancreatic neuroendocrine tumors in order to decipher when and how the most aggressive subclones emerge.