Mariano Barbacid, PhD
Professor of Molecular Oncology, Centro Nacional de Ivestigaciones Oncológicas, Madrid, Spain
Best known as one of three researchers who isolated, for the first time, a human oncogene, H-Ras, Dr. Barbacid is an international leader in studies involving the molecular basis of cancer. Ras oncogenes have now been implicated in approximately one-fifth of all human cancers, including those with especially poor prognoses such as non-small-cell lung carcinoma and pancreatic ductal adenocarcinoma. His work on Ras oncogenes and the possibility that they could be targeted chemically led to a decade-long leadership position in the pharmaceutical industry, where he worked to fast-track approval of new drugs.
Dr. Barbacid conducted most of his research in the United States until 1998 when he returned to his native Spain to establish the new Centro Nacional de Investigaciones Oncológicas (Spanish National Cancer Research Center), where he served as its first director until 2011. In this capacity, he recruited scientists from all over the world for the new center, which in just 10 years became one of the leading research institutions in Europe.
Dr. Barbacid continues his quest to validate molecular targets in Ras-driven tumors using sophisticated genetic approaches in genetically engineered mouse models with the ultimate goal of developing therapeutic strategies that, in the not too distant future, may prove useful in the clinic.
2012 Elected Foreign Member, National Academy of Sciences, Washington, DC2011 Endowed Chair on Molecular Oncology, AXA Research Fund, Paris2007 Medal of Honor, International Agency for Cancer Research2005 Charles Rodolphe Brupbacher Cancer Research Prize, Zurich2004 Elected Member, Academia Europea, London1996 Elected Member, European Molecular Biology Organization1994 Ipsen Prize, Paris1989-1992 Board of Directors, AACR1988 Joseph Steiner Prize, Bern1986 AACR Award for Outstanding Achievement in Cancer Research1984 King Juan Carlos I Award, Madrid1983 Distinguished Young Scientist, Maryland Academy of Sciences1974 PhD, Universidad Complutense, Madrid