John E. Dick, PhD FRS
Canada Research Chair in Stem Cell Biology and Senior Scientist, Princess Margaret Cancer Centre and McEwen Centre for Regenerative Medicine, University Health Network; Professor of Molecular Genetics, University of Toronto; Director, Program in Cancer Stem Cells, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
A pioneer in the fields of stem cell biology and molecular hematology, Dr. Dick is widely known for his discovery and characterization of normal hematopoietic stem cells (HSC) isolated from both bone marrow and umbilical cord blood and leukemic stem cells (LSC) from acute myeloid leukemia (AML) patients. He provided the first detailed description of human LSC establishing that AML is organized as a hierarchy sustained by LSC. He showed that compared to total AML cells, the gene expression signatures of LSC are the best predictors of clinical outcome pointing to their clinical relevance. His findings stimulated research in solid tumors leading to a broader interest in the cancer stem cell model to describe tumor heterogeneity. He also demonstrated that the entire hematopoietic system and its various cell types can be regenerated from a single HSC.Dr. Dick utilized such stem cells to create humanized mouse models that recapitulated both normal human blood cell development and human leukemia. Most notably, he developed a novel xenograft repopulation experimental system using NOD/SCID mice, commonly referred to as an in vivo repopulation assay or in vivo stem cell assay. In this assay, HSC and/or LSC are transplanted into immunocompromised mice as a means to study stem cell biology, hematopoiesis, and leukemogenic processes since the transplanted cells are able to survive and proliferate in the weakened immune system environment of the mouse. This assay has enabled detailed characterization of the molecular properties of various cancer-initiating cells for many leukemias and solid tumors. Importantly, by studying the normal human hematopoietic cells that remain present in blood samples taken from AML patients, Dr. Dick has been able to backtrack the evolutionary steps leading to leukemia all the way to the cell of origin. Thus the experimental systems he has created enable better understanding of the pathogenesis of many blood-related diseases including leukemia.
2014 Elected Fellow, The Royal Society, London2013 Canadian Cancer Research Alliance Award for Outstanding Achievements in Cancer Research2009 E. Donnall Thomas Prize, American Society of Hematology2009 Clifford Prize for Cancer Research, University of Adelaide, Australia2009 Men of Distinction Award, Israel Cancer Research Fund2008 G.H.A. Clowes Memorial Award, American Association for Cancer Research2007 Donald Metcalf Award, International Society for Experimental Hematology2007 Premier's Summit Award in Medical Research, Province of Ontario2007 Diamond Jubilee Award (joint with JE Till and EA McCulloch), National Cancer Institute of Canada2005 Dameshek Prize, American Society of Hematology2004 Elected Fellow, Royal Society of Canada, Academy of Sciences2002 Herman Boerhaave Medal, Leiden University, The Netherlands2000 Robert L. Noble Prize for Excellence in Cancer Research, National Cancer Institute of Canada1997 Michael Smith Prize, Canadian Institutes for Health Research1984 PhD, University of Manitoba