In the United States, about four in ten of the 1.9 million new cancer cases and nearly half of all cancer deaths are related to potentially preventable causes, including tobacco use, obesity, exposure to ultraviolet light, and vaccine-preventable infections with cancer-associated pathogens.

The AACR is committed to advancing the science of cancer prevention. We work with a wide range of partners in biomedical research to develop strategies and promising therapeutics to stop cancer before it starts.

Our ten peer-reviewed medical journals including Cancer Epidemiology, Biomarkers & Prevention and Cancer Prevention Research feature leading-edge research in the field.

Adopting healthy lifestyles that eliminate or reduce the risk of recognized causes of cancer, could decrease the number of people diagnosed with many forms of the disease. Moreover, healthy approaches to living can reduce the risk of cancer recurrences and improve outcomes during treatment. 

Tobacco use including smoking has been shown to increase the risk for 17 types of cancer in addition to lung cancer. Eliminating tobacco use is the single most important step we can take to reduce the burden of cancer.

Poor diet, lack of physical activity, and obesity/overweight are known risk factors for many chronic diseases and conditions, and are estimated to account for about 20 percent of cancers in the United States. 

The relationship between diet and cancer is complex. Because people consume a variety of foods that keep changing every day, the contribution of a specific type of food or food component in preventing a type of cancer is difficult to determine.

Exposure to ultraviolet (UV) light from the sun or indoor tanning is the predominant cause of all three main types of skin cancer – basal cell carcinoma, squamous cell carcinoma, and melanoma. Adopting sun-safe habits and avoiding the use of indoor tanning devices can decrease the incidence of skin cancer.

Infections with cancer-related pathogens account for about one in five cancer diagnoses worldwide, and taking measures to prevent and treat these infections can help prevent certain cancers. 


Screening for colorectal cancer, the second leading cause of cancer death in the United States, by colonoscopy can both detect these cancers at an early stage, when successful treatment is more likely, and prevent them from developing in the first place. That’s because precancerous polyps found by colonoscopy can be removed during the procedure, thus preventing them from going on to become cancers.

If everyone followed colorectal cancer screening guidelines, at least 60 percent of colorectal cancer deaths in the United States could be avoided. Unfortunately, just 38 percent of adults in the United States are getting screened as recommended.

Similarly, Pap test screening for cervical cancer, which was diagnosed in more than 14,000 U.S. women in 2022 can both detect cancer at an early stage, when treatment outcomes tend to be better, and detect precancerous abnormalities, which can then be treated to prevent them developing into cancers.


Scientists are studying many different ways to prevent cancer, including: