Class of 2021
Scientific Areas of Expertise: Cancer Cell Biology; Invasion and Metastasis; Protein Kinases
For renowned contributions to the understanding of oncogenic transformation including discovering that RSV v-Src transforming protein and c-Src are plasma membrane-associated, defining the activation mechanism of the c-Src tyrosine kinase; discovering that c-Src is involved in polyomavirus transformation, which revolutionized the DNA tumor virus field; and identifying Tks4 and Tks5 adaptor proteins as Src substrates that trigger invadopodia formation and protease secretion essential for tumor cell invasion.