The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine

The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine represents a joint effort to encourage and support postdoctoral or clinical research fellows to conduct highly novel and provocative research in the field of regenerative cancer medicine and to establish a successful career path in this field. Funded research is directly related to the enhancement of the physiology of cancer survivors.

2019 Grantee

Alfredo Oliveros, PhD

Alfredo Oliveros, PhD

Postdoctoral Fellow
Mayo Clinic
Rochester, Minnesota
Caffeine as a novel Adora2a regenerative strategy for treating chemobrain

Research
Cisplatin chemotherapy, although efficacious in cancer treatment, potentiates off-target cognitive dysfunction, known as chemobrain. RNA-sequencing of hippocampal tissue derived from cisplatin-treated mice revealed upregulation of the adenosine A2A receptor (Adora2a). Dr. Oliveros hypothesizes that Adora2a inhibition can prevent chemobrain. He is set to use a DREADDs (designer receptors exclusively activated by designer drugs) approach to inhibit Adora2a-expressing neurons. In addition, he is set to determine whether caffeine, an Adora2a antagonist, can attenuate cisplatin-induced chemobrain.

Biography
Dr. Oliveros obtained his PhD in Biomedical Sciences at Mayo Clinic College of Medicine. His post-doctoral investigations at Mayo Clinic focus on how chemotherapy-induced cognitive dysfunction affects the regenerative neurobiology of cancer survivors.

Acknowledgement of Support
Throughout my scientific career, I have endeavored to study how neurological disease detrimentally affects human behavior. Receipt of this generous award will allow me to successfully bridge the disciplines of cancer-biology and neurobiology to foster novel discoveries to benefit cancer survivors, while paving the way toward becoming an independent scientist.