The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine
The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine represents a joint effort to encourage and support postdoctoral or clinical research fellows to conduct highly novel and provocative research in the field of regenerative cancer medicine and to establish a successful career path in this field. Funded research is directly related to the enhancement of the physiology of cancer survivors.
Cisplatin chemotherapy, although efficacious in cancer treatment, potentiates off-target cognitive dysfunction, known as chemobrain. RNA-sequencing of hippocampal tissue derived from cisplatin-treated mice revealed upregulation of the adenosine A2A receptor (Adora2a). Dr. Oliveros hypothesizes that Adora2a inhibition can prevent chemobrain. He is set to use a DREADDs (designer receptors exclusively activated by designer drugs) approach to inhibit Adora2a-expressing neurons. In addition, he is set to determine whether caffeine, an Adora2a antagonist, can attenuate cisplatin-induced chemobrain.
Dr. Oliveros obtained his PhD in Biomedical Sciences at Mayo Clinic College of Medicine. His post-doctoral investigations at Mayo Clinic focus on how chemotherapy-induced cognitive dysfunction affects the regenerative neurobiology of cancer survivors.
Acknowledgement of Support
Throughout my scientific career, I have endeavored to study how neurological disease detrimentally affects human behavior. Receipt of this generous award will allow me to successfully bridge the disciplines of cancer-biology and neurobiology to foster novel discoveries to benefit cancer survivors, while paving the way toward becoming an independent scientist.