GENIE 17.0-Public Release

Featured Cancer

March is Multiple Myeloma awareness month. Multiple Myeloma is a cancer of plasma cells found within the bone marrow. Each year, approximately 36,000 new cases are diagnosed in the United States. As discussed in a recent blog post, ongoing advancements in treatment and research are leading to improved patient outcomes, with innovative therapies like CAR T-cell treatments and bispecific engagers offering more personalized and effective regimens.​

​The #AACRGENIE 17.0 public release provides a detailed look at the genomic landscape of Multiple Myeloma, offering valuable insights. The registry includes 1,167 patients and 1,548 samples, helping to deepen our understanding of this cancer. KRAS, TP53, NRAS, and DNMT3A are the most frequently mutated genes among other key mutations. These data highlight several guideline recognized alterations, including the TP53 deletions as well as FGFR3 and NSD2 fusions. ​

#AACRGENIE, celebrating a decade of collaboration and powering the future of precision oncology. ​
​Explore the Multiple Myeloma data on cBioPortal.

The LATEST

• GENIE data was presented in a poster session at ASCO #GU25.
  Abstract Title: DNA damage repair alterations as predictive biomarker for platinum-based chemotherapy in metastatic urothelial cancer.
• The latest GENIE publication: Collaborating across sectors in service of open science, precision oncology, and patients: an overview of the AACR Project GENIE (Genomics Evidence Neoplasia Information Exchange) Biopharma Collaborative (BPC) – ScienceDirect, Elsevier, Volume 7, March 2025.
• A snapshot of a year of progress: 2024_Year_in_Review.
• Watch the latest Believe in Progress episode: AACR Project GENIE: A Conversation with Shawn M. Sweeney, PhD, and Philippe L. Bedard, MD.
• New public data portal available from Sage Bionetworks.
• The BioPharma Collaborative’s CRC v2.0-Public and NSCLC 2.0-Public datasets are now available.
• Learn more about AACR Project GENIE data included as part of sotorasib regulatory approval.

Visit AACR PROJECT GENIE® BLOG for further information.