Sir Paul M. Nurse, PhD
Director, Francis Crick Institute, London, England
A renowned geneticist and cell biologist and a 2001 Nobel Laureate, Dr. Nurse has expanded the fundamental understanding of the cell cycle and its regulation by isolating and classifying the proteins that govern the process. His best- known contribution to unraveling the mysteries of cell cycle regulation was his discovery of the cell division cycle 2 (cdc2) gene in Schizosaccharomyces pombe. He concluded that the gene was responsible for contributing to cell cycle control at both the G1-S and G2-M checkpoints. Dr. Nurse later isolated, cloned, and characterized the human homologue of cdc2, referred to as cyclin-dependent kinase 1 (CDK1).
Further research involving such proteins as CDK1 has demonstrated that these kinases are vital to numerous biologic functions, capable of inducing large-scale molecular changes through their inherent phosphorylation capability. This class of proteins has since become an attractive area for anticancer drug discovery and development.
2017 Anthony Cerami Award in Translational Medicine, Feinstein Institute2010 Director, Francis Crick Institute2010 President, Royal Society of London2006 Elected Foreign Honorary Member, American Academy of Arts and Sciences2005 Copley Medal, Royal Society, London2003-2010 President, Rockefeller University2002 Chief Executive, Cancer Research UK2002 Legion of Honor (France)2001 Nobel Prize in Physiology or Medicine1999 Knight Bachelor of the British Empire (Queen’s Birthday Honours List)1998 Albert Lasker Award for Basic Medical Research1997 Alfred P. Sloan, Jr., Prize, General Motors Cancer Research Foundation1995 Royal Medal, Royal Society, London1995 Elected Foreign Associate, National Academy of Sciences, Washington, D.C.1993 Director of Research, Imperial Cancer Research Fund, London1992 Gairdner Foundation International Award1973 PhD, University of East Anglia