Please note that this meeting will take place as an in-person event in San Diego and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the registration page for details.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

*-Short talk from proffered abstract

Friday, September 25

• Welcome and Opening Keynote Address

Saturday, September 26

• Plenary Session 1: From Detection to Interception: Redefining the Earliest Stages of Pancreatic Cancer
• Stephenson Global Prize Award Presentation and Honorary Lecture
• Plenary Session 2: Pancreatic Cancer Biology: From Mechanism to Disease Evolution
• Plenary Session 3: Integrating AI and Multi-Omics in Precision Cancer Modeling

Sunday, September 27

• Plenary Session 4: The Desmoplastic and Neural Microenvironment of Pancreatic Cancer
• Plenary Session 5: Reimagining Immunotherapy in Pancreatic Cancer
• Plenary Session 6: The 3 Rs of RAS Inhibition: Response, Resistance, and Rational Combinations
• Panel Discussion: Accelerating First-in-Human Oncology Trials Through Regulatory Innovation

Monday, September 28

• Plenary Session 7: Smarter Clinical Trials and Precision Development
• Plenary Session 8: Spatial Biology and Actionable Tumor Ecosystems

REGISTRATION

3-9 p.m.

WELCOME AND OPENING Keynote

6-7:45 p.m.

• 6 p.m. | Welcome and Introduction of Keynote Speaker
• 6:15 p.m. | Opening Keynote Lecture
  Andrew J. Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts
• 7:05 p.m. | Rising Star Keynote
  Eileen Carpenter, University of Michigan Medical School, Ann Arbor, Michigan

Opening Reception

7:45-9:30 p.m.

Breakfast

7-8:30 a.m.

Plenary Session 1: From Detection to Interception: Redefining the Earliest Stages of Pancreatic Cancer

8:30-10:15 a.m.

Session Chair: Diane M. Simeone, University of California, San Diego, California

• 8:30 a.m. | Diane M. Simeone
• 8:55 a.m. | Getting ahead of the tumor: Interception approaches for pancreas cancer
  Ben Z. Stanger, University of Pennsylvania, Philadelphia, Pennsylvania
• 9:15 a.m. | Nuria Mallats, Spanish National Cancer Research Centre, Madrid, Spain

Short talks selected from proffered abstracts

Break

10:15-10:30 a.m.

Stephenson Global Prize Award Presentation and Honorary Lecture

10:30 a.m.-12 p.m.

Lunch

12-2 p.m.

Plenary Session 2: Pancreatic Cancer Biology: From Mechanism to Disease Evolution

2-3:45 p.m.

Session Chair: Andrew J. Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts

• 2:05 p.m. | Organelle-driven metabolic adaptation in pancreatic cancer progression
  Rushika M. Perera, University of California, San Francisco, California
• 2:25 p.m. | Speaker to be announced
• 2:45 p.m. | Plasma WGS in pancreatic cancer
  Faiyaz Notta, University of Toronto, Toronto, Ontario, Canada

Short talks selected from proffered abstracts

Break

3:45-4 p.m.

Plenary Session 3: Integrating AI and Multi-Omics in Precision Cancer Modeling

4-5:45 p.m.

Session Chair: Colin D. Weekes, Massachusetts General Hospital, Boston, Massachusetts

• 4:05 p.m. | From multi-omics to autonomous artificial intelligence agents in pancreatic cancer
  Enrique Velázquez Villareal, City of Hope Comprehensive Cancer Center, Duarte, California
• 4:25 p.m. | Computationally assisted patient finding of pancreatic cancer for improving care delivery and research
  Daniel Alexander King, Monter Cancer Center, Lake Success, New York
• 4:45 p.m. | The future of oncology is now: AI applications in clinicians’ frontline
  Joo Kyung Park, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Short talks selected from proffered abstracts

Break

5:45-6 p.m.

Poster Session a/reception

6-8 p.m.

Breakfast

7-8:30 a.m.

“Meet the Expert” Roundtables Session

7:15-8:15 a.m.

Plenary Session 4: The Desmoplastic and Neural Microenvironment of Pancreatic Cancer

8:30-10:15 a.m.

Session Chair: To be announced

• 8:35 a.m. | Extracting mechanisms of cell cross-talk in pancreatic cancer using spatial and single-cell multi-omics
  Nina Steele, University of Cincinnati, Cincinnati, Ohio
• 8:55 a.m. | Speaker to be announced
• 9:15 a.m. | Speaker to be announced

Short talks selected from proffered abstracts

break

10:15-10:30 a.m.

Plenary Session 5: Reimagining Immunotherapy in Pancreatic Cancer

10:30 a.m.-12:15 p.m.

Session Chair: Florencia McAllister, The University of Texas MD Anderson Cancer Center, Houston, Texas

• 10:30 a.m. | Florencia McAllister
• 10:55 a.m. | Targeting the antigen landscape that emerges after KRAS inhibition for PDAC immunotherapy
  Alex Jaeger, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
• 11:15 a.m. | Determinants of B cell fate and function in cancer
  Yuliya Pylayeva-Gupta, University of North Carolina, Chapell Hill, North Carolina

Short talks selected from proffered abstracts

Lunch on Own

12-2 p.m.

Plenary Session 6: The 3 Rs of RAS Inhibition: Response, Resistance, and Rational Combinations

2-3:45 p.m.

Session Chair: Kenneth P. Olive, Herbert Irving Comprehensive Cancer Center, New York, New York

• 2 p.m. | Kenneth P. Olive
• 2:25 p.m. | Exploring limitless possibilities in limited time: the future of KRAS targeting
  Nilofer Azad, Johns Hopkins University, Baltimore, Maryland
• 2:45 p.m. | Genetic co-gain in MYC and KRAS drives resistance to targeting KRAS signaling in pancreatic ductal adenocarcinoma
  Rosalie Sears, Oregon Health and Science University, Portland, Oregon

Short talks selected from proffered abstracts

break

3:45-4 p.m.

Panel Discussion: Accelerating First-in-Human Oncology Trials Through Regulatory Innovation

4-5 p.m.

Moderator: Diane M. Simeone, University of California, San Diego, California

Poster Session B/Reception

5-7 p.m.

Breakfast

7-8:30 a.m.

Plenary Session 7: Smarter Clinical Trials and Precision Development

8:30-10:15 a.m.

Session Chair: Eileen O’Reilly, Memorial Sloan Kettering Cancer Center, New York, New York

• 8:35 a.m. | Eileen O’Reilly
• 8:55 a.m. | Speaker to be announced
• 9:15 a.m. | A new perspective: Clinical trials in the era of RAS-inhibitors
  Christoph Benedikt Westphalen, Ludwig Maximilian University of Munich, Munich, Germany

Short talks selected from proffered abstracts

break

10:15-10:30 a.m.

Plenary Session 8: Spatial Biology and Actionable Tumor Ecosystems

10:30 a.m.-12:15 p.m.

Session Chair: To be announced

• 10:35 a.m. | Forecasting the interplay between tumor-CAF-immune ecosystems by integrating spatial multiomics and mechanistic mathematical modeling
  Elana Fertig, University of Maryland, Baltimore, Maryland
• 10:55 a.m. | Speaker to be announced
• 11:15 a.m. | Decoding actionable tumor ecosystems through spatial multi-omics and AI
  Linghua Wang, The University of Texas MD Anderson Cancer Center, Houston, Texas

Short talks selected from proffered abstracts

Closing Remarks

12:15 p.m.